Detailed information of TA system TA020811

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1328400..1328986
• Replicon: chromosome
• Accession: NC_004350
• Organism: Streptococcus mutans UA159

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: SMU_RS06380
• Protein ID: WP_002263545.1
• Coordinates: 1328795..1328986 (-)
• Length: 64 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Q8DTE7
• Locus tag: SMU_RS06375
• Protein ID: WP_002263544.1
• Coordinates: 1328400..1328777 (-)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SMU_RS06360 (SMU.1396)	1324324..1326075	-	1752	WP_002262719.1	glucan-binding protein	-
SMU_RS06365 (SMU.1397c)	1326238..1326523	-	286	Protein_1228	helix-turn-helix transcriptional regulator	-
SMU_RS06370 (SMU.1398)	1326838..1327731	+	894	WP_002262721.1	LexA family transcriptional regulator IrvR	-
SMU_RS06375 (SMU.1400c)	1328400..1328777	-	378	WP_002263544.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
SMU_RS06380	1328795..1328986	-	192	WP_002263545.1	type II toxin-antitoxin system HicA family toxin	Toxin
SMU_RS06385 (SMU.1402c)	1329083..1329745	-	663	WP_002263546.1	type II-A CRISPR-associated protein Csn2	-
SMU_RS06390 (SMU.1403c)	1329735..1330079	-	345	WP_002263547.1	CRISPR-associated endonuclease Cas2	-
SMU_RS06395 (SMU.1404c)	1330076..1330942	-	867	WP_002352326.1	type II CRISPR-associated endonuclease Cas1	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-61)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (5-106)

Sequences

Toxin

Protein

• Length: 64 a.a.
• Molecular weight: 7139.47 Da
• Isoelectric Point: 10.6223

>T20811 WP_002263545.1 NC_004350:c1328986-1328795 [Streptococcus mutans UA159]
MPLTGKELAKLAINNGWEEVRVRGSHHHFKKDGVSYIVTIPIHGNKVLKIGLEKKLLRDLNLL

Nucleotide

• Length: 192 bp

>T20811 NC_004350:c1328986-1328795 [Streptococcus mutans UA159]
TTGCCATTAACAGGGAAAGAATTAGCTAAATTAGCGATAAACAATGGATGGGAAGAAGTTCGGGTGAGAGGAAGTCATCA
TCATTTCAAGAAAGATGGAGTATCTTATATTGTGACGATTCCTATTCATGGAAATAAAGTGCTTAAAATTGGTCTTGAAA
AGAAACTCTTAAGGGATTTAAATTTATTATGA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 14264.31 Da
• Isoelectric Point: 4.5540

>AT20811 WP_002263544.1 NC_004350:c1328777-1328400 [Streptococcus mutans UA159]
MLKSYPVIFHKEEEGYWVEFPEFGGGTQGEDLEEAMKNARQMLESVLASYLDEGLVLPISSDIQKISVEDGFATMIQADP
SPYLKNNKAIRKNVTVPEWLIRLADRDRVNYSEVLTKALEKKLQL

Nucleotide

• Length: 378 bp

>AT20811 NC_004350:c1328777-1328400 [Streptococcus mutans UA159]
ATGTTAAAATCATATCCTGTAATTTTTCATAAGGAAGAGGAAGGGTATTGGGTTGAATTTCCTGAATTTGGCGGTGGTAC
GCAAGGGGAAGATTTGGAAGAAGCCATGAAGAACGCTCGTCAGATGTTAGAAAGTGTGTTGGCATCTTATCTTGATGAAG
GGTTGGTTCTACCCATTTCAAGCGATATTCAGAAAATATCTGTTGAAGATGGTTTTGCGACCATGATTCAAGCTGATCCT
AGTCCTTATCTCAAAAATAACAAAGCTATTCGGAAAAATGTTACCGTGCCTGAGTGGTTGATACGATTAGCAGACCGTGA
CCGAGTAAATTATTCTGAAGTATTAACAAAGGCTTTGGAAAAGAAACTACAATTATAA

Structures

Antitoxin

• AlphaFold DB: Q8DTE7