Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 2188932..2189455 Replicon chromosome
Accession NZ_CP077853
Organism Staphylococcus aureus strain N5

Toxin (Protein)


Gene name relE Uniprot ID A0A3A5LQI3
Locus tag KU499_RS10665 Protein ID WP_000074049.1
Coordinates 2189189..2189455 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag KU499_RS10660 Protein ID WP_000587616.1
Coordinates 2188932..2189189 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU499_RS10645 (2185429) 2185429..2186178 - 750 WP_000072461.1 CPBP family lipoprotein N-acylation protein LnsB -
KU499_RS10650 (2186373) 2186373..2187950 + 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
KU499_RS10655 (2188118) 2188118..2188573 - 456 WP_000732076.1 DUF1307 domain-containing protein -
KU499_RS10660 (2188932) 2188932..2189189 + 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KU499_RS10665 (2189189) 2189189..2189455 + 267 WP_000074049.1 Txe/YoeB family addiction module toxin Toxin
KU499_RS10670 (2189810) 2189810..2190886 + 1077 WP_001076673.1 M42 family metallopeptidase -
KU499_RS10675 (2191134) 2191134..2191796 + 663 WP_000923526.1 ATP-binding cassette domain-containing protein -
KU499_RS10680 (2191789) 2191789..2192565 + 777 WP_000072149.1 iron export ABC transporter permease subunit FetB -
KU499_RS10685 (2192961) 2192961..2194148 + 1188 WP_000026189.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10676.24 Da        Isoelectric Point: 10.1597

>T208100 WP_000074049.1 NZ_CP077853:2189189-2189455 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T208100 NZ_CP103567:c5245886-5245503 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCATCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT208100 WP_000587616.1 NZ_CP077853:2188932-2189189 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT208100 NZ_CP103567:c5246128-5245886 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A5LQI3

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References