Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1676121..1676598 Replicon chromosome
Accession NZ_CP077852
Organism Staphylococcus aureus strain N6

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag KU516_RS08260 Protein ID WP_000052076.1
Coordinates 1676121..1676309 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag KU516_RS08265 Protein ID WP_001059690.1
Coordinates 1676338..1676598 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU516_RS08230 (1672115) 1672115..1672636 + 522 WP_000824482.1 hypothetical protein -
KU516_RS08235 (1672977) 1672977..1673663 + 687 WP_000141557.1 thermonuclease family protein -
KU516_RS08240 (1674020) 1674020..1674220 + 201 WP_001059082.1 cold-shock protein -
KU516_RS08245 (1674712) 1674712..1674930 - 219 WP_000005886.1 hypothetical protein -
KU516_RS08250 (1674992) 1674992..1675276 - 285 WP_001004399.1 hypothetical protein -
KU516_RS08255 (1675364) 1675364..1675933 - 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
KU516_RS08260 (1676121) 1676121..1676309 - 189 WP_000052076.1 hypothetical protein Toxin
KU516_RS08265 (1676338) 1676338..1676598 - 261 WP_001059690.1 hypothetical protein Antitoxin
KU516_RS08270 (1676939) 1676939..1677142 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
KU516_RS08275 (1677139) 1677139..1677375 - 237 WP_000349581.1 hypothetical protein -
KU516_RS08280 (1677600) 1677600..1678181 + 582 WP_001140693.1 histidine phosphatase family protein -
KU516_RS08285 (1678254) 1678254..1678871 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
KU516_RS08290 (1679026) 1679026..1679520 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
KU516_RS08295 (1679919) 1679919..1680341 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
KU516_RS08300 (1680489) 1680489..1681205 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T208092 WP_000052076.1 NZ_CP077852:c1676309-1676121 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T208092 NZ_CP103567:837140-837625 [Klebsiella pneumoniae]
ATGATCTTGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGACCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTAGTTAAT
GCCTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT208092 WP_001059690.1 NZ_CP077852:c1676598-1676338 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT208092 NZ_CP103567:836850-837143 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References