Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 186445..186974 Replicon chromosome
Accession NZ_CP077852
Organism Staphylococcus aureus strain N6

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag KU516_RS01065 Protein ID WP_000621175.1
Coordinates 186445..186807 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag KU516_RS01070 Protein ID WP_000948331.1
Coordinates 186804..186974 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU516_RS01045 (183423) 183423..184193 - 771 WP_001041111.1 RNA polymerase sigma factor SigB -
KU516_RS01050 (184168) 184168..184647 - 480 WP_001190829.1 anti-sigma B factor RsbW -
KU516_RS01055 (184649) 184649..184975 - 327 WP_001052491.1 anti-sigma factor antagonist -
KU516_RS01060 (185094) 185094..186095 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
KU516_RS01065 (186445) 186445..186807 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KU516_RS01070 (186804) 186804..186974 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
KU516_RS01075 (187059) 187059..188207 - 1149 WP_001281154.1 alanine racemase -
KU516_RS01080 (188273) 188273..188632 - 360 WP_000581197.1 holo-ACP synthase -
KU516_RS01085 (188636) 188636..189127 - 492 WP_001205912.1 PH domain-containing protein -
KU516_RS01090 (189114) 189114..190697 - 1584 WP_001294626.1 PH domain-containing protein -
KU516_RS01095 (190690) 190690..191169 - 480 WP_001287087.1 hypothetical protein -
KU516_RS01100 (191377) 191377..191937 - 561 WP_001092411.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T208084 WP_000621175.1 NZ_CP077852:c186807-186445 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T208084 NZ_CP103563:c98140-97991 [Escherichia coli O25b:H4-ST131]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT208084 WP_000948331.1 NZ_CP077852:c186974-186804 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT208084 NZ_CP103563:98184-98245 [Escherichia coli O25b:H4-ST131]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References