Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3251380..3252046 Replicon chromosome
Accession NZ_CP077850
Organism Erwinia amylovora strain CP200242 isolate missinsg

Toxin (Protein)


Gene name cptA Uniprot ID A0A830ZTB8
Locus tag KTR61_RS14685 Protein ID WP_004161808.1
Coordinates 3251380..3251799 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID D4HWC2
Locus tag KTR61_RS14690 Protein ID WP_004155593.1
Coordinates 3251780..3252046 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTR61_RS14670 (KTR61_14645) 3247372..3249051 + 1680 WP_004155599.1 type III effector -
KTR61_RS14675 (KTR61_14650) 3249561..3250514 + 954 WP_004155597.1 DMT family transporter -
KTR61_RS14680 (KTR61_14655) 3250744..3251262 + 519 WP_004155596.1 flavodoxin FldB -
KTR61_RS14685 (KTR61_14660) 3251380..3251799 - 420 WP_004161808.1 protein YgfX Toxin
KTR61_RS14690 (KTR61_14665) 3251780..3252046 - 267 WP_004155593.1 FAD assembly factor SdhE Antitoxin
KTR61_RS14695 (KTR61_14670) 3252272..3253258 + 987 WP_004155590.1 tRNA-modifying protein YgfZ -
KTR61_RS14700 (KTR61_14675) 3253259..3253918 - 660 WP_004155588.1 hemolysin III family protein -
KTR61_RS14705 (KTR61_14680) 3254131..3254739 + 609 WP_004155587.1 HD domain-containing protein -
KTR61_RS14710 (KTR61_14685) 3254844..3255573 - 730 Protein_2834 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(8-79)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 16366.46 Da        Isoelectric Point: 11.9444

>T208077 WP_004161808.1 NZ_CP077850:c3251799-3251380 [Erwinia amylovora]
VVLWQCELRPSRLAQRFSLLLHGAVMLALLLPTWPASSGLVRMLLLVLVLLECIRSRRRIGRRQGDIALLEGHELRWRQR
EWCIISRPWLTGQAILLLLQDTHGQRERLWLFADGMEKRNWRQLRLQLLNSKVQGNGWC

Download         Length: 420 bp

>T208077 NZ_CP103562:c4314975-4314688 [Escherichia coli O25b:H4-ST131]
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTAGTGTTTGATGATCCACAACATTTGTCACAGCAAGATCGCATAGAAAACGGTGAGTATCGCTGGCAGACTATCGGCC
TGGTTCACGGTATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAGCCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10498.07 Da        Isoelectric Point: 6.4605

>AT208077 WP_004155593.1 NZ_CP077850:c3252046-3251780 [Erwinia amylovora]
MDITNKSRIHWACRRGMRELDISIMPFFQYEFDSLNDSDKRLFVRLLESDDPDLFNWLMNHGEPADVELKRMVALIQQRN
KQRGPVAM

Download         Length: 267 bp

>AT208077 NZ_CP103562:c4314701-4314399 [Escherichia coli O25b:H4-ST131]
ATGAGCATGGTTAAACATAAACGAGGGACACCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCACTGGCGAA
TAAATTCGACGAAGATATTGATTACAGTGATATCCCGCCTTCCAGCGATGAGCAATGGTCTAACGCAGAACGCGGTAAGT
TTTATCGGCCATTGAAAACCCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGCTGAAGCGACCTGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A830ZTB8

Antitoxin

Source ID Structure
AlphaFold DB A0A831A3F0

References