Detailed information of TA system TA208073

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 1106073..1106526
• Replicon: chromosome
• Accession: NZ_CP077850
• Organism: Erwinia amylovora strain CP200242 isolate missinsg

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KTR61_RS04830
• Protein ID: WP_013035888.1
• Coordinates: 1106290..1106526 (+)
• Length: 79 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: D4HZA2
• Locus tag: KTR61_RS04825
• Protein ID: WP_004159527.1
• Coordinates: 1106073..1106300 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KTR61_RS04815 (KTR61_04790)	1104997..1105401	+	405	WP_013035886.1	hypothetical protein	-
KTR61_RS04820 (KTR61_04795)	1105465..1105752	-	288	WP_004159528.1	SymE family type I addiction module toxin	-
KTR61_RS04825 (KTR61_04800)	1106073..1106300	+	228	WP_004159527.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
KTR61_RS04830 (KTR61_04805)	1106290..1106526	+	237	WP_013035888.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KTR61_RS04835 (KTR61_04810)	1106513..1106731	-	219	WP_004159522.1	hypothetical protein	-
KTR61_RS04840 (KTR61_04815)	1107059..1109275	+	2217	Protein_928	ferrichrome porin FhuA	-
KTR61_RS04845 (KTR61_04820)	1109324..1110118	+	795	WP_004159512.1	Fe3+-hydroxamate ABC transporter ATP-binding protein FhuC	-
KTR61_RS04850 (KTR61_04825)	1110133..1111011	+	879	WP_004159509.1	Fe(3+)-hydroxamate ABC transporter substrate-binding protein FhuD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-78)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-75)

Sequences

Toxin

Protein

• Length: 79 a.a.
• Molecular weight: 9135.79 Da
• Isoelectric Point: 9.0876

>T208073 WP_013035888.1 NZ_CP077850:1106290-1106526 [Erwinia amylovora]
ISYELLFDPWALKEWKKLGATVREQFKKKLAEVLVNLQVESARLRDHPDCCKIKLKSSGYRLVYQVQDEQLVMLVISV

Nucleotide

• Length: 237 bp

>T208073 NZ_CP103562:c3727808-3727506 [Escherichia coli O25b:H4-ST131]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8435.90 Da
• Isoelectric Point: 7.9766

>AT208073 WP_004159527.1 NZ_CP077850:1106073-1106300 [Erwinia amylovora]
VRLDDKLKSKACAVLDELDVSPTEAVRLLFQYIAENERLPLKALTVSDEKDALLKTVRERLASLQKGIKVTLDKL

Nucleotide

• Length: 228 bp

>AT208073 NZ_CP103562:c3727470-3727129 [Escherichia coli O25b:H4-ST131]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG

Structures

Antitoxin

• AlphaFold DB: A0A831A410