Detailed information of TA system TA208067

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 447985..448638
• Replicon: chromosome
• Accession: NZ_CP077846
• Organism: Acinetobacter baumannii strain DETAB-P24

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: KU228_RS02180
• Protein ID: WP_000607077.1
• Coordinates: 448249..448638 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: KU228_RS02175
• Protein ID: WP_001288210.1
• Coordinates: 447985..448242 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU228_RS02155 (KU228_02155)	443501..444508	+	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-
KU228_RS02160 (KU228_02160)	444527..444904	+	378	WP_001216380.1	50S ribosomal protein L17	-
KU228_RS02165 (KU228_02165)	445086..446576	+	1491	WP_000415125.1	NAD(P)/FAD-dependent oxidoreductase	-
KU228_RS02170 (KU228_02170)	446625..447797	-	1173	WP_001190542.1	acyl-CoA dehydrogenase family protein	-
KU228_RS02175 (KU228_02175)	447985..448242	+	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
KU228_RS02180 (KU228_02180)	448249..448638	+	390	WP_000607077.1	membrane protein	Toxin
KU228_RS02185 (KU228_02185)	449408..450493	+	1086	WP_000049106.1	hypothetical protein	-
KU228_RS02190 (KU228_02190)	450571..451137	+	567	WP_000651538.1	rhombosortase	-
KU228_RS02195 (KU228_02195)	451325..453520	+	2196	WP_001158906.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15552.88 Da
• Isoelectric Point: 10.4313

>T208067 WP_000607077.1 NZ_CP077846:448249-448638 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T208067 NZ_CP103562:1975895-1976146 [Escherichia coli O25b:H4-ST131]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGACAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT208067 WP_001288210.1 NZ_CP077846:447985-448242 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT208067 NZ_CP103562:1976143-1976397 [Escherichia coli O25b:H4-ST131]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAGCAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAACTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCTTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7