Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 450392..451045 Replicon chromosome
Accession NZ_CP077840
Organism Acinetobacter baumannii strain DETAB-P90

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag KU251_RS02190 Protein ID WP_000607077.1
Coordinates 450656..451045 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag KU251_RS02185 Protein ID WP_001288210.1
Coordinates 450392..450649 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU251_RS02165 (KU251_02165) 445908..446915 + 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -
KU251_RS02170 (KU251_02170) 446934..447311 + 378 WP_001216380.1 50S ribosomal protein L17 -
KU251_RS02175 (KU251_02175) 447493..448983 + 1491 WP_000415125.1 NAD(P)/FAD-dependent oxidoreductase -
KU251_RS02180 (KU251_02180) 449032..450204 - 1173 WP_001190542.1 acyl-CoA dehydrogenase family protein -
KU251_RS02185 (KU251_02185) 450392..450649 + 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
KU251_RS02190 (KU251_02190) 450656..451045 + 390 WP_000607077.1 membrane protein Toxin
KU251_RS02195 (KU251_02195) 451815..452900 + 1086 WP_000049106.1 hypothetical protein -
KU251_RS02200 (KU251_02200) 452978..453544 + 567 WP_000651538.1 rhombosortase -
KU251_RS02205 (KU251_02205) 453732..455927 + 2196 WP_001158906.1 TRAP transporter large permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15552.88 Da        Isoelectric Point: 10.4313

>T208061 WP_000607077.1 NZ_CP077840:450656-451045 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T208061 NZ_CP103562:229400-229507 [Escherichia coli O25b:H4-ST131]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT208061 WP_001288210.1 NZ_CP077840:450392-450649 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT208061 NZ_CP103562:c229343-229286 [Escherichia coli O25b:H4-ST131]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References