Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | BrnTA/BrnT-BrnA |
| Location | 2762..3350 | Replicon | plasmid pDETAB10 |
| Accession | NZ_CP077839 | ||
| Organism | Acinetobacter baumannii strain DETAB-E159 | ||
Toxin (Protein)
| Gene name | brnT | Uniprot ID | A0A3G6Z3M6 |
| Locus tag | KU204_RS19640 | Protein ID | WP_000438826.1 |
| Coordinates | 2762..3049 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | brnA | Uniprot ID | N9M5I3 |
| Locus tag | KU204_RS19645 | Protein ID | WP_001983304.1 |
| Coordinates | 3036..3350 (+) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KU204_RS19620 (KU204_19535) | 1..951 | + | 951 | WP_001205343.1 | replication initiation protein RepM | - |
| KU204_RS19625 (KU204_19540) | 944..1519 | + | 576 | WP_001096616.1 | plasmid replication DNA-binding protein | - |
| KU204_RS19630 (KU204_19545) | 1539..1682 | + | 144 | WP_001125246.1 | hypothetical protein | - |
| KU204_RS19635 (KU204_19550) | 1871..2389 | - | 519 | WP_000447193.1 | tetratricopeptide repeat protein | - |
| KU204_RS19640 (KU204_19555) | 2762..3049 | + | 288 | WP_000438826.1 | BrnT family toxin | Toxin |
| KU204_RS19645 (KU204_19560) | 3036..3350 | + | 315 | WP_001983304.1 | BrnA antitoxin family protein | Antitoxin |
| KU204_RS19650 (KU204_19565) | 3478..5889 | + | 2412 | WP_000932953.1 | TonB-dependent receptor ZnuD2 | - |
| KU204_RS19655 (KU204_19570) | 6194..6655 | + | 462 | WP_000761346.1 | DIP1984 family protein | - |
| KU204_RS19660 (KU204_19575) | 6978..7151 | - | 174 | WP_001282484.1 | hypothetical protein | - |
| KU204_RS19665 (KU204_19580) | 7151..7522 | - | 372 | WP_000504218.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..8731 | 8731 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11303.72 Da Isoelectric Point: 6.0889
>T208060 WP_000438826.1 NZ_CP077839:2762-3049 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG
Download Length: 288 bp
>T208060 NZ_CP103562:228917-229024 [Escherichia coli O25b:H4-ST131]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA
Antitoxin
Download Length: 105 a.a. Molecular weight: 12208.84 Da Isoelectric Point: 7.2026
>AT208060 WP_001983304.1 NZ_CP077839:3036-3350 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ
Download Length: 315 bp
>AT208060 NZ_CP103562:c228868-228803 [Escherichia coli O25b:H4-ST131]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3G6Z3M6 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | N9M5I3 |