Detailed information of TA system TA208056

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3312610..3313292
• Replicon: chromosome
• Accession: NZ_CP077835
• Organism: Acinetobacter baumannii strain DETAB-P65

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: KU217_RS15670
• Protein ID: WP_000009390.1
• Coordinates: 3312610..3312789 (+)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A1S2G1M8
• Locus tag: KU217_RS15675
• Protein ID: WP_000878688.1
• Coordinates: 3312879..3313292 (+)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU217_RS15650 (KU217_15595)	3308406..3309266	-	861	WP_071211542.1	GPO family capsid scaffolding protein	-
KU217_RS15655 (KU217_15600)	3309444..3311222	+	1779	WP_071211543.1	terminase family protein	-
KU217_RS15660 (KU217_15605)	3311219..3312268	+	1050	WP_062936692.1	phage portal protein	-
KU217_RS15665 (KU217_15610)	3312278..3312493	+	216	WP_071211544.1	hypothetical protein	-
KU217_RS15670 (KU217_15615)	3312610..3312789	+	180	WP_000009390.1	type II toxin-antitoxin system HicA family toxin	Toxin
KU217_RS15675 (KU217_15620)	3312879..3313292	+	414	WP_000878688.1	hypothetical protein	Antitoxin
KU217_RS15680 (KU217_15625)	3313561..3314415	-	855	WP_071211545.1	SH3 domain-containing protein	-
KU217_RS15705 (KU217_15650)	3315546..3316610	-	1065	WP_001278262.1	quinolinate synthase NadA	-
KU217_RS15710 (KU217_15655)	3316757..3317977	-	1221	WP_002067802.1	bifunctional glutamate N-acetyltransferase/amino-acid acetyltransferase ArgJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3270862..3313292	42430

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (10-78)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6799.11 Da
• Isoelectric Point: 11.1422

>T208056 WP_000009390.1 NZ_CP077835:3312610-3312789 [Acinetobacter baumannii]
MSFNEFKRWLIAQGVIFVRKGKGSHMIIEFNGKKTVFPNHGKKEIPEGTRLKIKKDLGL

Nucleotide

• Length: 180 bp

>T208056 NZ_CP103560:c5002542-5001625 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCAATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 15511.84 Da
• Isoelectric Point: 5.2905

>AT208056 WP_000878688.1 NZ_CP077835:3312879-3313292 [Acinetobacter baumannii]
MKYYVSIVQEEGAYIVSSRDLPLLNSVGYTLEEALSEALDGIETTFEIYMDERKAIPLPSKGKKDEYEIHLPVRVAAKVR
LYNEMISQDVTKAELARRLGWLQKQADRLLSLKHSTKLESIESAFHALGKDLDIVVA

Nucleotide

• Length: 414 bp

>AT208056 NZ_CP103560:c5003306-5002548 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A1S2G1M8