Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 446480..447133 Replicon chromosome
Accession NZ_CP077835
Organism Acinetobacter baumannii strain DETAB-P65

Toxin (Protein)


Gene name cptA Uniprot ID A0A1S2G112
Locus tag KU217_RS02180 Protein ID WP_071210859.1
Coordinates 446744..447133 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag KU217_RS02175 Protein ID WP_001288210.1
Coordinates 446480..446737 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU217_RS02155 (KU217_02155) 441995..443002 + 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -
KU217_RS02160 (KU217_02160) 443021..443398 + 378 WP_001216380.1 50S ribosomal protein L17 -
KU217_RS02165 (KU217_02165) 443580..445070 + 1491 WP_016686239.1 NAD(P)/FAD-dependent oxidoreductase -
KU217_RS02170 (KU217_02170) 445120..446292 - 1173 WP_071210858.1 acyl-CoA dehydrogenase family protein -
KU217_RS02175 (KU217_02175) 446480..446737 + 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
KU217_RS02180 (KU217_02180) 446744..447133 + 390 WP_071210859.1 hypothetical protein Toxin
KU217_RS02185 (KU217_02185) 447903..448988 + 1086 WP_000049106.1 hypothetical protein -
KU217_RS02190 (KU217_02190) 449067..449633 + 567 WP_000651536.1 rhombosortase -
KU217_RS02195 (KU217_02195) 449821..452016 + 2196 WP_071210860.1 TRAP transporter large permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15690.01 Da        Isoelectric Point: 10.4623

>T208055 WP_071210859.1 NZ_CP077835:446744-447133 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFINFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKKLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T208055 NZ_CP103560:c4841446-4841162 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT208055 WP_001288210.1 NZ_CP077835:446480-446737 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT208055 NZ_CP103560:c4841678-4841436 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGGTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S2G112

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References