Detailed information of TA system TA208052

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1193731..1194382
• Replicon: chromosome
• Accession: NZ_CP077832
• Organism: Acinetobacter baumannii strain DETAB-P43

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: KU224_RS05655
• Protein ID: WP_000838146.1
• Coordinates: 1193731..1193913 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A0J1AAF8
• Locus tag: KU224_RS05660
• Protein ID: WP_000966689.1
• Coordinates: 1193978..1194382 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU224_RS05610 (KU224_05615)	1188988..1189653	+	666	WP_038337351.1	Ish1 domain-containing protein	-
KU224_RS05615 (KU224_05620)	1189658..1190047	+	390	WP_000008492.1	hypothetical protein	-
KU224_RS05620 (KU224_05625)	1190049..1190417	+	369	WP_000524231.1	hypothetical protein	-
KU224_RS05625 (KU224_05630)	1190426..1190830	+	405	WP_000248324.1	hypothetical protein	-
KU224_RS05630 (KU224_05635)	1190802..1191170	+	369	WP_000539752.1	hypothetical protein	-
KU224_RS05635 (KU224_05640)	1191172..1191570	+	399	WP_001132270.1	hypothetical protein	-
KU224_RS05640 (KU224_05645)	1191572..1191784	+	213	WP_000121166.1	hypothetical protein	-
KU224_RS05645 (KU224_05650)	1191892..1192821	+	930	WP_000094300.1	phage tail tube protein	-
KU224_RS05650 (KU224_05655)	1192866..1193399	+	534	WP_001185622.1	hypothetical protein	-
KU224_RS05655 (KU224_05660)	1193731..1193913	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
KU224_RS05660 (KU224_05665)	1193978..1194382	+	405	WP_000966689.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
KU224_RS05665 (KU224_05670)	1194463..1194864	+	402	WP_000720591.1	hypothetical protein	-
KU224_RS05670 (KU224_05675)	1194925..1198890	+	3966	WP_000191304.1	tape measure protein	-
KU224_RS05675 (KU224_05680)	1199008..1199349	+	342	WP_001281459.1	phage tail protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1164708..1212750	48042

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T208052 WP_000838146.1 NZ_CP077832:1193731-1193913 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T208052 NZ_CP103560:4076482-4076700 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14769.78 Da
• Isoelectric Point: 4.5000

>AT208052 WP_000966689.1 NZ_CP077832:1193978-1194382 [Acinetobacter baumannii]
MLYPIAIERGTDTEAFGVSVPDIPGCFSAGDTLYEAIENVKEAISGHLEILAEDGEEIPLASDVSKFIDQEDYRGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT208052 NZ_CP103560:4076081-4076455 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: A0A0J1AAF8