Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 449155..449808 Replicon chromosome
Accession NZ_CP077832
Organism Acinetobacter baumannii strain DETAB-P43

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag KU224_RS02190 Protein ID WP_000607077.1
Coordinates 449419..449808 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag KU224_RS02185 Protein ID WP_001288210.1
Coordinates 449155..449412 (+) Length 86 a.a.

Genomic Context

KU224_RS02165KU224_RS02170KU224_RS02175KU224_RS02185KU224_RS02190KU224_RS02195KU224_RS02200KU224_RS02205KU224_RS02180
Location: 444671..445678 (1008 bp)
Type: Others
Protein ID: WP_000198631.1
Location: 445697..446074 (378 bp)
Type: Others
Protein ID: WP_001216380.1
Location: 446256..447746 (1491 bp)
Type: Others
Protein ID: WP_000415125.1
Location: 449155..449412 (258 bp)
Type: Antitoxin
Protein ID: WP_001288210.1
Location: 449419..449808 (390 bp)
Type: Toxin
Protein ID: WP_000607077.1
Location: 450578..451663 (1086 bp)
Type: Others
Protein ID: WP_000049106.1
Location: 451741..452307 (567 bp)
Type: Others
Protein ID: WP_000651538.1
Location: 452495..454690 (2196 bp)
Type: Others
Protein ID: WP_001158906.1
Location: 447795..448967 (1173 bp)
Type: Others
Protein ID: WP_001190542.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
KU224_RS02165 (KU224_02165)444671..445678+1008WP_000198631.1DNA-directed RNA polymerase subunit alpha-
KU224_RS02170 (KU224_02170)445697..446074+378WP_001216380.150S ribosomal protein L17-
KU224_RS02175 (KU224_02175)446256..447746+1491WP_000415125.1NAD(P)/FAD-dependent oxidoreductase-
KU224_RS02180 (KU224_02180)447795..448967-1173WP_001190542.1acyl-CoA dehydrogenase family protein-
KU224_RS02185 (KU224_02185)449155..449412+258WP_001288210.1succinate dehydrogenase assembly factor 2Antitoxin
KU224_RS02190 (KU224_02190)449419..449808+390WP_000607077.1membrane proteinToxin
KU224_RS02195 (KU224_02195)450578..451663+1086WP_000049106.1hypothetical protein-
KU224_RS02200 (KU224_02200)451741..452307+567WP_000651538.1rhombosortase-
KU224_RS02205 (KU224_02205)452495..454690+2196WP_001158906.1TRAP transporter large permease subunit-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15552.88 Da        Isoelectric Point: 10.4313

>T208051 WP_000607077.1 NZ_CP077832:449419-449808 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T208051 NZ_CP103560:c2711099-2709777 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTACTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCGGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
AAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCTACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT208051 WP_001288210.1 NZ_CP077832:449155-449412 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT208051 NZ_CP103560:c2711365-2711099 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGATGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A7U4BQM7

References