Detailed information of TA system TA020805

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 4837822..4838372
• Replicon: chromosome
• Accession: NC_004347
• Organism: Shewanella oneidensis MR-1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q8E8M2
• Locus tag: SO_RS21560
• Protein ID: WP_011074235.1
• Coordinates: 4837822..4838127 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q8E8M1
• Locus tag: SO_RS21565
• Protein ID: WP_011074236.1
• Coordinates: 4838115..4838372 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SO_RS21535 (SO_4636)	4833024..4834301	-	1278	WP_011074230.1	lipoprotein	-
SO_RS21540 (SO_4637)	4834390..4835058	+	669	WP_011074231.1	response regulator transcription factor	-
SO_RS21545 (SO_4638)	4835030..4836322	+	1293	WP_011074232.1	HAMP domain-containing histidine kinase	-
SO_RS21550 (SO_4639)	4836413..4836802	+	390	WP_011074233.1	NirD/YgiW/YdeI family stress tolerance protein	-
SO_RS21555 (SO_4640)	4836904..4837380	-	477	WP_011074234.1	peroxiredoxin	-
SO_RS21560 (SO_4641)	4837822..4838127	-	306	WP_011074235.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SO_RS21565 (SO_4642)	4838115..4838372	-	258	WP_011074236.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
SO_RS21570 (SO_4643)	4838514..4838843	-	330	WP_011074237.1	hypothetical protein	-
SO_RS21575 (SO_4812)	4839143..4840975	-	1833	WP_011074238.1	hypothetical protein	-
SO_RS21580 (SO_4645)	4841297..4842214	-	918	WP_011074239.1	choice-of-anchor H family protein	-
SO_RS21585 (SO_4646)	4842582..4842881	+	300	WP_011074240.1	PepSY domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 11862.92 Da
• Isoelectric Point: 5.2182

>T20805 WP_011074235.1 NC_004347:c4838127-4837822 [Shewanella oneidensis MR-1]
MAEIIWTEPALADLNDIAEYIALENIVAAKQLVQMVFAKVERLVDFPDSGRIPPELERLNYREVVVNPCRVFYKYGDEKV
RILFVMRAERDLRRFMLTRAC

Nucleotide

• Length: 306 bp

>T20805 NC_004347:c4838127-4837822 [Shewanella oneidensis MR-1]
ATGGCTGAAATAATTTGGACGGAACCTGCTTTAGCTGATCTGAATGATATTGCTGAATATATCGCGCTTGAAAATATCGT
TGCTGCCAAGCAACTGGTTCAAATGGTTTTTGCAAAGGTTGAGCGTTTAGTCGATTTTCCCGATTCAGGGCGTATTCCAC
CAGAACTAGAGCGGCTCAATTATCGTGAAGTGGTGGTAAATCCATGTCGTGTTTTCTACAAGTATGGCGATGAAAAGGTT
CGAATTCTTTTTGTTATGCGTGCGGAAAGAGATTTGCGTCGTTTTATGCTGACTAGGGCGTGTTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9675.21 Da
• Isoelectric Point: 7.3181

>AT20805 WP_011074236.1 NC_004347:c4838372-4838115 [Shewanella oneidensis MR-1]
MKVELVTSLKRQATKILADLHETKEPVLITEHGKPSAYLIDVEDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Nucleotide

• Length: 258 bp

>AT20805 NC_004347:c4838372-4838115 [Shewanella oneidensis MR-1]
ATGAAAGTGGAACTCGTGACGTCACTAAAACGTCAAGCAACTAAGATCCTTGCCGATCTGCATGAGACCAAAGAACCAGT
ATTGATCACTGAGCATGGTAAACCGTCAGCTTATCTTATTGATGTAGAAGATTATGAGTTTATGCAAAATCGTTTGGCGA
TTCTTGAAGGTATTGCACGTGGTGAGCGAGCTTTAGCGGATGGAAAAGTCGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGCTGAAATAA

Structures

Toxin

• AlphaFold DB: Q8E8M2

Antitoxin

• AlphaFold DB: Q8E8M1