Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1221742..1222393 Replicon chromosome
Accession NZ_CP077830
Organism Acinetobacter baumannii strain DETAB-E51

Toxin (Protein)


Gene name hicA Uniprot ID S3TWT7
Locus tag KU058_RS05855 Protein ID WP_000838146.1
Coordinates 1221742..1221924 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J1AAF8
Locus tag KU058_RS05860 Protein ID WP_000966689.1
Coordinates 1221989..1222393 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU058_RS05810 (KU058_05815) 1216999..1217664 + 666 WP_038337351.1 Ish1 domain-containing protein -
KU058_RS05815 (KU058_05820) 1217669..1218058 + 390 WP_000008492.1 hypothetical protein -
KU058_RS05820 (KU058_05825) 1218060..1218428 + 369 WP_000524231.1 hypothetical protein -
KU058_RS05825 (KU058_05830) 1218437..1218841 + 405 WP_000248324.1 hypothetical protein -
KU058_RS05830 (KU058_05835) 1218813..1219181 + 369 WP_000539752.1 hypothetical protein -
KU058_RS05835 (KU058_05840) 1219183..1219581 + 399 WP_001132270.1 hypothetical protein -
KU058_RS05840 (KU058_05845) 1219583..1219795 + 213 WP_000121166.1 hypothetical protein -
KU058_RS05845 (KU058_05850) 1219903..1220832 + 930 WP_000094300.1 phage tail tube protein -
KU058_RS05850 (KU058_05855) 1220877..1221410 + 534 WP_001185622.1 hypothetical protein -
KU058_RS05855 (KU058_05860) 1221742..1221924 + 183 WP_000838146.1 type II toxin-antitoxin system HicA family toxin Toxin
KU058_RS05860 (KU058_05865) 1221989..1222393 + 405 WP_000966689.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KU058_RS05865 (KU058_05870) 1222474..1222875 + 402 WP_000720591.1 hypothetical protein -
KU058_RS05870 (KU058_05875) 1222936..1226901 + 3966 WP_000191304.1 tape measure protein -
KU058_RS05875 (KU058_05880) 1227019..1227360 + 342 WP_001281459.1 phage tail protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1192990..1242451 49461


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6695.84 Da        Isoelectric Point: 10.5523

>T208049 WP_000838146.1 NZ_CP077830:1221742-1221924 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T208049 NZ_CP103560:1991075-1991177 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14769.78 Da        Isoelectric Point: 4.5000

>AT208049 WP_000966689.1 NZ_CP077830:1221989-1222393 [Acinetobacter baumannii]
MLYPIAIERGTDTEAFGVSVPDIPGCFSAGDTLYEAIENVKEAISGHLEILAEDGEEIPLASDVSKFIDQEDYRGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT208049 NZ_CP103560:c1991184-1991039 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S3TWT7

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1AAF8

References