Detailed information of TA system TA208048

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 449201..449854
• Replicon: chromosome
• Accession: NZ_CP077830
• Organism: Acinetobacter baumannii strain DETAB-E51

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: KU058_RS02185
• Protein ID: WP_000607077.1
• Coordinates: 449465..449854 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: KU058_RS02180
• Protein ID: WP_001288210.1
• Coordinates: 449201..449458 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU058_RS02160 (KU058_02160)	444717..445724	+	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-
KU058_RS02165 (KU058_02165)	445743..446120	+	378	WP_001216380.1	50S ribosomal protein L17	-
KU058_RS02170 (KU058_02170)	446302..447792	+	1491	WP_000415125.1	NAD(P)/FAD-dependent oxidoreductase	-
KU058_RS02175 (KU058_02175)	447841..449013	-	1173	WP_001190542.1	acyl-CoA dehydrogenase family protein	-
KU058_RS02180 (KU058_02180)	449201..449458	+	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
KU058_RS02185 (KU058_02185)	449465..449854	+	390	WP_000607077.1	membrane protein	Toxin
KU058_RS02190 (KU058_02190)	450624..451709	+	1086	WP_000049106.1	hypothetical protein	-
KU058_RS02195 (KU058_02195)	451787..452353	+	567	WP_000651538.1	rhombosortase	-
KU058_RS02200 (KU058_02200)	452541..454736	+	2196	WP_001158906.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15552.88 Da
• Isoelectric Point: 10.4313

>T208048 WP_000607077.1 NZ_CP077830:449465-449854 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T208048 NZ_CP103560:811305-811715 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT208048 WP_001288210.1 NZ_CP077830:449201-449458 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT208048 NZ_CP103560:811058-811324 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7