Detailed information of TA system TA208045

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 460387..461040
• Replicon: chromosome
• Accession: NZ_CP077828
• Organism: Acinetobacter baumannii strain DETAB-E351

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: KUY52_RS02255
• Protein ID: WP_000607077.1
• Coordinates: 460651..461040 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: KUY52_RS02250
• Protein ID: WP_001288210.1
• Coordinates: 460387..460644 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KUY52_RS02230 (KUY52_02235)	455903..456910	+	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-
KUY52_RS02235 (KUY52_02240)	456929..457306	+	378	WP_001216380.1	50S ribosomal protein L17	-
KUY52_RS02240 (KUY52_02245)	457488..458978	+	1491	WP_000415125.1	NAD(P)/FAD-dependent oxidoreductase	-
KUY52_RS02245 (KUY52_02250)	459027..460199	-	1173	WP_001190542.1	acyl-CoA dehydrogenase family protein	-
KUY52_RS02250 (KUY52_02255)	460387..460644	+	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
KUY52_RS02255 (KUY52_02260)	460651..461040	+	390	WP_000607077.1	membrane protein	Toxin
KUY52_RS02260 (KUY52_02265)	461810..462895	+	1086	WP_000049106.1	hypothetical protein	-
KUY52_RS02265 (KUY52_02270)	462973..463539	+	567	WP_000651538.1	rhombosortase	-
KUY52_RS02270 (KUY52_02275)	463727..465922	+	2196	WP_001158906.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15552.88 Da
• Isoelectric Point: 10.4313

>T208045 WP_000607077.1 NZ_CP077828:460651-461040 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T208045 NZ_CP103559:c5116637-5116326 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTGTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT208045 WP_001288210.1 NZ_CP077828:460387-460644 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT208045 NZ_CP103559:c5116325-5116035 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACACCCTTC
ACGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGAAC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACTGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAGGCACTTAACCGTTAG

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7