Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1246650..1247301 Replicon chromosome
Accession NZ_CP077826
Organism Acinetobacter baumannii strain DETAB-E108

Toxin (Protein)


Gene name hicA Uniprot ID S3TWT7
Locus tag KU053_RS06040 Protein ID WP_000838146.1
Coordinates 1246650..1246832 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J1AAF8
Locus tag KU053_RS06045 Protein ID WP_000966689.1
Coordinates 1246897..1247301 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU053_RS05995 (KU053_05990) 1241907..1242572 + 666 WP_038337351.1 Ish1 domain-containing protein -
KU053_RS06000 (KU053_05995) 1242577..1242966 + 390 WP_000008492.1 hypothetical protein -
KU053_RS06005 (KU053_06000) 1242968..1243336 + 369 WP_000524231.1 hypothetical protein -
KU053_RS06010 (KU053_06005) 1243345..1243749 + 405 WP_000248324.1 hypothetical protein -
KU053_RS06015 (KU053_06010) 1243721..1244089 + 369 WP_000539752.1 hypothetical protein -
KU053_RS06020 (KU053_06015) 1244091..1244489 + 399 WP_001132270.1 hypothetical protein -
KU053_RS06025 (KU053_06020) 1244491..1244703 + 213 WP_000121166.1 hypothetical protein -
KU053_RS06030 (KU053_06025) 1244811..1245740 + 930 WP_000094300.1 phage tail tube protein -
KU053_RS06035 (KU053_06030) 1245785..1246318 + 534 WP_001185622.1 hypothetical protein -
KU053_RS06040 (KU053_06035) 1246650..1246832 + 183 WP_000838146.1 type II toxin-antitoxin system HicA family toxin Toxin
KU053_RS06045 (KU053_06040) 1246897..1247301 + 405 WP_000966689.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KU053_RS06050 (KU053_06045) 1247382..1247783 + 402 WP_000720591.1 hypothetical protein -
KU053_RS06055 (KU053_06050) 1247844..1251809 + 3966 WP_000191304.1 tape measure protein -
KU053_RS06060 (KU053_06055) 1251927..1252268 + 342 WP_001281459.1 phage tail protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1202707..1284810 82103


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6695.84 Da        Isoelectric Point: 10.5523

>T208044 WP_000838146.1 NZ_CP077826:1246650-1246832 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T208044 NZ_CP103559:c4820520-4820347 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14769.78 Da        Isoelectric Point: 4.5000

>AT208044 WP_000966689.1 NZ_CP077826:1246897-1247301 [Acinetobacter baumannii]
MLYPIAIERGTDTEAFGVSVPDIPGCFSAGDTLYEAIENVKEAISGHLEILAEDGEEIPLASDVSKFIDQEDYRGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT208044 NZ_CP103559:c4820844-4820548 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCATTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S3TWT7

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1AAF8

References