Detailed information of TA system TA208043

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 458902..459555
• Replicon: chromosome
• Accession: NZ_CP077826
• Organism: Acinetobacter baumannii strain DETAB-E108

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: KU053_RS02250
• Protein ID: WP_000607077.1
• Coordinates: 459166..459555 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: KU053_RS02245
• Protein ID: WP_001288210.1
• Coordinates: 458902..459159 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU053_RS02225 (KU053_02225)	454418..455425	+	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-
KU053_RS02230 (KU053_02230)	455444..455821	+	378	WP_001216380.1	50S ribosomal protein L17	-
KU053_RS02235 (KU053_02235)	456003..457493	+	1491	WP_000415125.1	NAD(P)/FAD-dependent oxidoreductase	-
KU053_RS02240 (KU053_02240)	457542..458714	-	1173	WP_001190542.1	acyl-CoA dehydrogenase family protein	-
KU053_RS02245 (KU053_02245)	458902..459159	+	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
KU053_RS02250 (KU053_02250)	459166..459555	+	390	WP_000607077.1	membrane protein	Toxin
KU053_RS02255 (KU053_02255)	460325..461410	+	1086	WP_000049106.1	hypothetical protein	-
KU053_RS02260 (KU053_02260)	461488..462054	+	567	WP_000651538.1	rhombosortase	-
KU053_RS02265 (KU053_02265)	462242..464437	+	2196	WP_038350236.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15552.88 Da
• Isoelectric Point: 10.4313

>T208043 WP_000607077.1 NZ_CP077826:459166-459555 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T208043 NZ_CP103559:c4723560-4723210 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGTGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGGTGAGGTGGTGGAAGAGGC
GTTATTACGTTTGCAGGCGGTGGTGGAATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT208043 WP_001288210.1 NZ_CP077826:458902-459159 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT208043 NZ_CP103559:c4723805-4723554 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTTCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTACG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCACGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7