Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4312930..4313587 Replicon chromosome
Accession NZ_CP077824
Organism Klebsiella pneumoniae strain FF1009

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag KU661_RS20940 Protein ID WP_002916310.1
Coordinates 4312930..4313340 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag KU661_RS20945 Protein ID WP_002916312.1
Coordinates 4313321..4313587 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU661_RS20920 (KU661_20860) 4308930..4310663 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
KU661_RS20925 (KU661_20865) 4310669..4311382 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KU661_RS20930 (KU661_20870) 4311405..4312301 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
KU661_RS20935 (KU661_20875) 4312402..4312923 + 522 WP_002916308.1 flavodoxin FldB -
KU661_RS20940 (KU661_20880) 4312930..4313340 - 411 WP_002916310.1 protein YgfX Toxin
KU661_RS20945 (KU661_20885) 4313321..4313587 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
KU661_RS20950 (KU661_20890) 4313833..4314816 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
KU661_RS20955 (KU661_20895) 4314967..4315626 - 660 WP_002916317.1 hemolysin III family protein -
KU661_RS20960 (KU661_20900) 4315790..4316101 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
KU661_RS20965 (KU661_20905) 4316151..4316879 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
KU661_RS20970 (KU661_20910) 4316998..4318431 + 1434 WP_065801036.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T208041 WP_002916310.1 NZ_CP077824:c4313340-4312930 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T208041 NZ_CP103559:c4207353-4206955 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAGCCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGAAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT208041 WP_002916312.1 NZ_CP077824:c4313587-4313321 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT208041 NZ_CP103559:c4207649-4207356 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAATCCAGCAAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CAGAACAAGAGGAGAAAAAACTGGTGAAGGCGCGCTTCCGTCCGAGTGCCGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References