Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 514984..515500 Replicon chromosome
Accession NZ_CP077824
Organism Klebsiella pneumoniae strain FF1009

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag KU661_RS02465 Protein ID WP_004178374.1
Coordinates 515216..515500 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag KU661_RS02460 Protein ID WP_002886901.1
Coordinates 514984..515226 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU661_RS02445 (KU661_02440) 511012..511752 + 741 WP_004186692.1 KDGP aldolase family protein -
KU661_RS02450 (KU661_02445) 511819..512973 + 1155 WP_117045626.1 lactonase family protein -
KU661_RS02455 (KU661_02450) 512996..514906 + 1911 WP_117045627.1 PRD domain-containing protein -
KU661_RS02460 (KU661_02455) 514984..515226 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KU661_RS02465 (KU661_02460) 515216..515500 + 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KU661_RS02470 (KU661_02465) 515504..515968 - 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KU661_RS02475 (KU661_02470) 516298..518436 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
KU661_RS02480 (KU661_02475) 518793..519536 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
KU661_RS02485 (KU661_02480) 519539..519712 - 174 WP_032409292.1 hypothetical protein -
KU661_RS02490 (KU661_02485) 519797..520105 + 309 WP_004178377.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T208028 WP_004178374.1 NZ_CP077824:515216-515500 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T208028 NZ_CP103559:c1905663-1905289 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT208028 WP_002886901.1 NZ_CP077824:514984-515226 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT208028 NZ_CP103559:c1906121-1905753 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References