Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5178811..5179436 Replicon chromosome
Accession NZ_CP077823
Organism Klebsiella africana strain FF1019

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KU660_RS24780 Protein ID WP_136031286.1
Coordinates 5178811..5179194 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KU660_RS24785 Protein ID WP_168435282.1
Coordinates 5179194..5179436 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU660_RS24765 (5176178) 5176178..5177080 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
KU660_RS24770 (5177077) 5177077..5177712 + 636 WP_008807902.1 formate dehydrogenase cytochrome b556 subunit -
KU660_RS24775 (5177709) 5177709..5178638 + 930 WP_136031288.1 formate dehydrogenase accessory protein FdhE -
KU660_RS24780 (5178811) 5178811..5179194 - 384 WP_136031286.1 type II toxin-antitoxin system VapC family toxin Toxin
KU660_RS24785 (5179194) 5179194..5179436 - 243 WP_168435282.1 CopG family transcriptional regulator Antitoxin
KU660_RS24790 (5179641) 5179641..5180558 + 918 WP_136031282.1 alpha/beta hydrolase -
KU660_RS24795 (5180572) 5180572..5181513 - 942 WP_012543287.1 fatty acid biosynthesis protein FabY -
KU660_RS24800 (5181558) 5181558..5181995 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
KU660_RS24805 (5181992) 5181992..5182852 - 861 WP_136031280.1 virulence factor BrkB family protein -
KU660_RS24810 (5182846) 5182846..5183445 - 600 WP_136031279.1 glucose-1-phosphatase -
KU660_RS24815 (5183576) 5183576..5184361 - 786 WP_136031277.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14361.64 Da        Isoelectric Point: 8.0552

>T208025 WP_136031286.1 NZ_CP077823:c5179194-5178811 [Klebsiella africana]
MTCGSALFDTNILIDLFSGRREAKQALEARPPQNAISLITWMEVMVGAKKYHQEQRTRMALSAFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTRDFAGIPGVVTPYELHPE

Download         Length: 384 bp

>T208025 NZ_CP103559:1169207-1169518 [Escherichia coli]
ATGCACATCATTTCGAAAGCGCCATTTGAAGAGTGTGCGCGCAAATATCCTAACGACGCTCTGGCTCTACACTCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACACCAGAAGAAATGCGAACGGCGTTTCCTAACCTCGACAATTTTAAATATC
GCAACAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACGAATCACGCAGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9551.82 Da        Isoelectric Point: 4.2500

>AT208025 WP_168435282.1 NZ_CP077823:c5179436-5179194 [Klebsiella africana]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDQAKDIISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp

>AT208025 NZ_CP103559:1169515-1169934 [Escherichia coli]
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAATATGAAAACAACAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCAGCAATGCCGGTT
GGCGTGGCCTTACTTCGTACGCTGATTGATCAACATAATTTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
TCTGGTCAGTCAGATTTTGTCTGGGCAACGATCCCTGACGATATCCCATATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References