Detailed information of TA system TA208024

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4859228..4860909
• Replicon: chromosome
• Accession: NZ_CP077823
• Organism: Klebsiella africana strain FF1019

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: KU660_RS23295
• Protein ID: WP_251354630.1
• Coordinates: 4859228..4860145 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: KU660_RS23300
• Protein ID: WP_251354631.1
• Coordinates: 4860151..4860909 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU660_RS23275 (4854534)	4854534..4856054	+	1521	WP_251354628.1	sugar ABC transporter ATP-binding protein	-
KU660_RS23280 (4856051)	4856051..4857049	+	999	WP_002885172.1	ribose ABC transporter permease	-
KU660_RS23285 (4857080)	4857080..4858021	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
KU660_RS23290 (4858096)	4858096..4859103	+	1008	WP_251354629.1	carbohydrate kinase family protein	-
KU660_RS23295 (4859228)	4859228..4860145	-	918	WP_251354630.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
KU660_RS23300 (4860151)	4860151..4860909	-	759	WP_251354631.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
KU660_RS23305 (4860995)	4860995..4861723	-	729	WP_251354632.1	response regulator transcription factor	-
KU660_RS23310 (4861996)	4861996..4864143	+	2148	WP_136029799.1	formate dehydrogenase subunit alpha	-
KU660_RS23315 (4864489)	4864489..4865175	+	687	WP_136029797.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (95-246)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34620.07 Da
• Isoelectric Point: 5.7845

>T208024 WP_251354630.1 NZ_CP077823:c4860145-4859228 [Klebsiella africana]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIADNLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLAVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDARELDRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIGLEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLAKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T208024 NZ_CP103559:1095509-1095844 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAGCTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28579.98 Da
• Isoelectric Point: 10.1009

>AT208024 WP_251354631.1 NZ_CP077823:c4860909-4860151 [Klebsiella africana]
MPTKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYTQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDVKGKILIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWFKRIDSQKIDLGAGKRQIVVNGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT208024 NZ_CP103559:1095261-1095509 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA