Detailed information of TA system TA208023

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4691450..4691966
• Replicon: chromosome
• Accession: NZ_CP077823
• Organism: Klebsiella africana strain FF1019

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KU660_RS22470
• Protein ID: WP_136030901.1
• Coordinates: 4691450..4691734 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: KU660_RS22475
• Protein ID: WP_136030903.1
• Coordinates: 4691724..4691966 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU660_RS22460 (4688403)	4688403..4690541	+	2139	WP_136030897.1	anaerobic ribonucleoside-triphosphate reductase	-
KU660_RS22465 (4690982)	4690982..4691446	+	465	WP_136030899.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
KU660_RS22470 (4691450)	4691450..4691734	-	285	WP_136030901.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KU660_RS22475 (4691724)	4691724..4691966	-	243	WP_136030903.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
KU660_RS22480 (4692044)	4692044..4693954	-	1911	WP_136030904.1	PRD domain-containing protein	-
KU660_RS22485 (4693977)	4693977..4695131	-	1155	WP_251354588.1	lactonase family protein	-
KU660_RS22490 (4695394)	4695394..4696134	-	741	WP_251354589.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-82)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-64)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11152.03 Da
• Isoelectric Point: 10.3787

>T208023 WP_136030901.1 NZ_CP077823:c4691734-4691450 [Klebsiella africana]
MTYELEFDPRAWREWQKLGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKAPGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T208023 NZ_CP103559:926196-926603 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATCTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATCCACGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGCTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9059.57 Da
• Isoelectric Point: 6.3340

>AT208023 WP_136030903.1 NZ_CP077823:c4691966-4691724 [Klebsiella africana]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVTLDDL

Nucleotide

• Length: 243 bp

>AT208023 NZ_CP103559:925949-926215 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAGTGTGACGATCCCGATC
TGTTTAACTGGCTGATGAACCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA