Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2636115..2637703 Replicon chromosome
Accession NZ_CP077823
Organism Klebsiella africana strain FF1019

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag KU660_RS12835 Protein ID WP_136034204.1
Coordinates 2636115..2637437 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag KU660_RS12840 Protein ID WP_136034491.1
Coordinates 2637437..2637703 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU660_RS12820 (2631171) 2631171..2633672 + 2502 WP_251355236.1 fimbria/pilus outer membrane usher protein -
KU660_RS12825 (2633660) 2633660..2634664 + 1005 WP_251355237.1 fimbrial protein -
KU660_RS12830 (2634806) 2634806..2636098 + 1293 WP_251354086.1 glycoside hydrolase family 10 protein -
KU660_RS12835 (2636115) 2636115..2637437 - 1323 WP_136034204.1 type II toxin-antitoxin system HipA family toxin Toxin
KU660_RS12840 (2637437) 2637437..2637703 - 267 WP_136034491.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
KU660_RS12845 (2637969) 2637969..2638295 - 327 WP_136034202.1 hydroxyisourate hydrolase -
KU660_RS12850 (2638292) 2638292..2638792 - 501 WP_136034200.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
KU660_RS12855 (2638770) 2638770..2640149 - 1380 WP_251354087.1 nucleobase:cation symporter-2 family protein -
KU660_RS12860 (2640493) 2640493..2641647 + 1155 WP_203032616.1 FAD-dependent urate hydroxylase HpxO -
KU660_RS12865 (2641628) 2641628..2642551 - 924 WP_251354088.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49302.57 Da        Isoelectric Point: 7.5367

>T208021 WP_136034204.1 NZ_CP077823:c2637437-2636115 [Klebsiella africana]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEALRWQTLDEAQLTSLLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGDHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLTLARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAMMSFLLGSSEALKDRNDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFMATAKAVNFPREQMLAILQEFAERVP
QTIESARRTLPADFSTHVWQAITENVLKLHARLQQGLQAL

Download         Length: 1323 bp

>T208021 NZ_CP103559:c622592-622128 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTACAGCGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAGCCCATTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9909.27 Da        Isoelectric Point: 8.5912

>AT208021 WP_136034491.1 NZ_CP077823:c2637703-2637437 [Klebsiella africana]
MNSPQIYSPVQLASYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKATETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT208021 NZ_CP103559:c622927-622592 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACACTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References