20802

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 723068..724609 Replicon chromosome
Accession NC_004347
Organism Shewanella oneidensis MR-1

Toxin (Protein)


Gene name hipA Uniprot ID Q8EIX3
Locus tag SO_RS03345 Protein ID WP_011071024.1
Coordinates 723308..724609 (+) Length 434 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID Q8EIX4
Locus tag SO_RS03340 Protein ID WP_011071023.1
Coordinates 723068..723304 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SO_RS03320 (SO_0701) 718091..719080 + 990 WP_011071019.1 LysR family transcriptional regulator -
SO_RS03325 (SO_0702) 719084..720442 - 1359 WP_011071020.1 MATE family efflux transporter -
SO_RS03330 (SO_0703) 720670..720960 + 291 WP_011071021.1 co-chaperone GroES -
SO_RS03335 (SO_0704) 721019..722656 + 1638 WP_011071022.1 chaperonin GroEL -
SO_RS03340 (SO_0705) 723068..723304 + 237 WP_011071023.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
SO_RS03345 (SO_0706) 723308..724609 + 1302 WP_011071024.1 type II toxin-antitoxin system toxin serine/threonine-protein kinase HipA Toxin
SO_RS03350 725102..725668 - 567 WP_164925615.1 hypothetical protein -
SO_RS03355 (SO_0708) 725665..726876 - 1212 WP_011071025.1 IS256-like element ISSod18 family transposase -
SO_RS03360 726928..727845 - 918 WP_164925616.1 hypothetical protein -
SO_RS03365 (SO_0710) 727827..729254 - 1428 WP_164925617.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 725665..726876 1211


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-64)


Sequences

Toxin        


Download         Length: 434 a.a.        Molecular weight: 48732.05 Da        Isoelectric Point: 5.4777

>T20802 WP_011071024.1 NC_004347:723308-724609 [Shewanella oneidensis MR-1]
MSTAKTLTLEMHLGDLMIGELSFDATADTFAVHYTKDWQQSGFPLSPTIPLDGTGTSNQISMFLVNLLPENKGLDYLIES
LGVSKGNTFALIRAIGLDTAGAIAFVPKGALLPETQLRPIKAEEVIQRIEDPTMWPMEIWDGKPRLSVAGVQPKLNLFYN
GKEFAFAEGTLSSTHIVKFEKYHHLVINEFITMRLAKVLGMNVANVDIVHFGRYKALCVERFDRRNIPGEQRVLRRHIVD
SCQALGFSVSKKYERNFGTGRDVKDIREGVSFNRLFSLAAKCRNPVAAKQDMLQWALFNLLTGNADAHGKNYSFFMTPSG
MEPTPWYDLVSVDMYEDFEQQLAMAIDDEFDPNSIYAYQLAAFMDGLGLPRNLLISNLTRIARRIPQAIAEVILMLPPLD
EDEASFVAHYKTQLLARCERYLGFVDEVRDVEV

Download         Length: 1302 bp

>T20802 NC_004347:723308-724609 [Shewanella oneidensis MR-1]
ATGAGTACAGCTAAAACGCTTACGCTAGAGATGCACCTCGGTGATTTAATGATCGGGGAGTTATCCTTTGATGCCACGGC
CGACACCTTTGCCGTGCATTACACCAAAGACTGGCAGCAAAGTGGATTTCCACTTTCACCAACTATTCCCTTAGATGGCA
CAGGAACGAGCAATCAAATATCAATGTTTTTGGTTAACTTATTGCCAGAAAACAAAGGATTAGATTATCTGATTGAATCG
CTTGGCGTCTCTAAGGGGAATACCTTTGCCTTGATCCGCGCCATTGGTCTCGATACCGCAGGCGCCATTGCTTTCGTTCC
TAAAGGGGCTTTACTGCCTGAAACACAATTGCGGCCAATTAAGGCTGAAGAAGTTATTCAACGCATTGAAGATCCCACAA
TGTGGCCGATGGAAATTTGGGACGGCAAACCTCGACTATCGGTAGCGGGTGTTCAACCTAAATTAAACCTGTTTTATAAC
GGGAAAGAATTTGCCTTTGCCGAAGGCACGCTGTCATCGACCCATATTGTTAAATTCGAAAAATATCATCATTTAGTGAT
CAATGAATTTATAACGATGCGCTTAGCCAAAGTGCTTGGGATGAATGTGGCGAATGTCGATATTGTTCATTTTGGCCGTT
ACAAAGCCCTTTGTGTTGAACGCTTTGACAGACGCAATATTCCAGGCGAGCAAAGAGTGTTAAGAAGGCACATTGTTGAT
AGCTGCCAAGCACTTGGTTTTAGTGTAAGCAAAAAATATGAACGTAATTTTGGTACGGGGCGCGATGTTAAAGATATTCG
TGAGGGGGTAAGTTTTAACAGGCTATTTAGTCTTGCCGCAAAATGCCGCAATCCCGTGGCAGCTAAGCAGGATATGCTGC
AATGGGCGCTATTCAATTTACTGACCGGCAATGCCGATGCACACGGTAAAAACTACTCATTTTTTATGACGCCAAGCGGA
ATGGAGCCAACTCCTTGGTACGATTTGGTCAGCGTAGATATGTATGAGGATTTTGAACAACAGCTTGCGATGGCTATTGA
TGACGAGTTTGATCCAAATAGCATTTACGCATATCAATTAGCCGCATTTATGGATGGTTTGGGTTTACCAAGAAATTTAT
TAATTAGTAACTTAACGAGAATAGCGCGAAGAATACCGCAGGCAATAGCGGAGGTGATTTTAATGCTCCCGCCCCTTGAT
GAAGATGAAGCATCATTTGTGGCTCATTACAAAACCCAGTTACTGGCGAGATGTGAACGTTACCTTGGTTTTGTTGACGA
GGTCAGGGATGTGGAAGTGTAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8501.82 Da        Isoelectric Point: 6.2232

>AT20802 WP_011071023.1 NC_004347:723068-723304 [Shewanella oneidensis MR-1]
MASPLNQQSLGLLIKERRKSAALTQDVAAMLCGVTKKTLIRVEKGEDVYISTVFKILDGLGIDIVSAQTSDTETNGWY

Download         Length: 237 bp

>AT20802 NC_004347:723068-723304 [Shewanella oneidensis MR-1]
ATGGCATCACCGTTAAATCAACAATCCCTCGGCTTGTTAATTAAAGAACGCAGGAAAAGTGCTGCTCTTACTCAAGACGT
GGCGGCCATGCTGTGCGGCGTAACCAAAAAAACGCTGATCCGAGTTGAAAAGGGCGAGGATGTTTATATCTCAACCGTAT
TCAAAATCCTTGATGGTCTGGGGATTGATATCGTTTCGGCTCAAACCAGCGACACCGAAACTAACGGCTGGTATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4PU5
PDB 4PU4
PDB 4PU3

Antitoxin

Source ID Structure
PDB 4PU4
PDB 4PU7
PDB 4PU3
PDB 4PU8
AlphaFold DB Q8EIX4

References