Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 802468..803125 Replicon chromosome
Accession NZ_CP077823
Organism Klebsiella africana strain FF1019

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag KU660_RS03955 Protein ID WP_002916310.1
Coordinates 802715..803125 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag KU660_RS03950 Protein ID WP_002916312.1
Coordinates 802468..802734 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU660_RS03925 (797638) 797638..799071 - 1434 WP_136029134.1 6-phospho-beta-glucosidase BglA -
KU660_RS03930 (799190) 799190..799918 - 729 WP_136029428.1 MurR/RpiR family transcriptional regulator -
KU660_RS03935 (799969) 799969..800280 + 312 WP_136029136.1 N(4)-acetylcytidine aminohydrolase -
KU660_RS03940 (800444) 800444..801103 + 660 WP_061153356.1 hemolysin III family protein -
KU660_RS03945 (801239) 801239..802222 - 984 WP_136029139.1 tRNA-modifying protein YgfZ -
KU660_RS03950 (802468) 802468..802734 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
KU660_RS03955 (802715) 802715..803125 + 411 WP_002916310.1 protein YgfX Toxin
KU660_RS03960 (803132) 803132..803653 - 522 WP_004144730.1 flavodoxin FldB -
KU660_RS03965 (803754) 803754..804650 + 897 WP_154041379.1 site-specific tyrosine recombinase XerD -
KU660_RS03970 (804673) 804673..805386 + 714 WP_136029141.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KU660_RS03975 (805392) 805392..807125 + 1734 WP_251354804.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T208009 WP_002916310.1 NZ_CP077823:802715-803125 [Klebsiella africana]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T208009 NZ_CP103557:c4497858-4497481 [Escherichia coli O25b:H4-ST131]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCAGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGTACCGACCTGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGATCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT208009 WP_002916312.1 NZ_CP077823:802468-802734 [Klebsiella africana]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT208009 NZ_CP103557:c4498316-4497948 [Escherichia coli O25b:H4-ST131]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References