Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4209510..4210167 Replicon chromosome
Accession NZ_CP077820
Organism Klebsiella pneumoniae strain FF1013

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag KU668_RS20460 Protein ID WP_002916310.1
Coordinates 4209510..4209920 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag KU668_RS20465 Protein ID WP_002916312.1
Coordinates 4209901..4210167 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU668_RS20440 (4205510) 4205510..4207243 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
KU668_RS20445 (4207249) 4207249..4207962 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KU668_RS20450 (4207985) 4207985..4208881 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
KU668_RS20455 (4208982) 4208982..4209503 + 522 WP_004144730.1 flavodoxin FldB -
KU668_RS20460 (4209510) 4209510..4209920 - 411 WP_002916310.1 protein YgfX Toxin
KU668_RS20465 (4209901) 4209901..4210167 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
KU668_RS20470 (4210413) 4210413..4211396 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
KU668_RS20475 (4211547) 4211547..4212206 - 660 WP_002916317.1 hemolysin III family protein -
KU668_RS20480 (4212370) 4212370..4212681 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
KU668_RS20485 (4212731) 4212731..4213459 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
KU668_RS20490 (4213578) 4213578..4215011 + 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T208004 WP_002916310.1 NZ_CP077820:c4209920-4209510 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T208004 NZ_CP103557:c3824853-3824551 [Escherichia coli O25b:H4-ST131]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT208004 WP_002916312.1 NZ_CP077820:c4210167-4209901 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT208004 NZ_CP103557:c3824515-3824174 [Escherichia coli O25b:H4-ST131]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References