Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 245535..247216 Replicon chromosome
Accession NZ_CP077820
Organism Klebsiella pneumoniae strain FF1013

Toxin (Protein)


Gene name mosT Uniprot ID A0A483YLF8
Locus tag KU668_RS01150 Protein ID WP_019724882.1
Coordinates 246299..247216 (+) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A6TH05
Locus tag KU668_RS01145 Protein ID WP_004177809.1
Coordinates 245535..246293 (+) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU668_RS01130 (241385) 241385..242071 - 687 WP_004151733.1 tetratricopeptide repeat protein -
KU668_RS01135 (242301) 242301..244448 - 2148 WP_077598858.1 formate dehydrogenase subunit alpha -
KU668_RS01140 (244721) 244721..245449 + 729 WP_002885152.1 response regulator transcription factor -
KU668_RS01145 (245535) 245535..246293 + 759 WP_004177809.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
KU668_RS01150 (246299) 246299..247216 + 918 WP_019724882.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
KU668_RS01155 (247341) 247341..248348 - 1008 WP_015959270.1 carbohydrate kinase family protein -
KU668_RS01160 (248423) 248423..249364 - 942 WP_002885156.1 ABC transporter substrate-binding protein -
KU668_RS01165 (249395) 249395..250393 - 999 WP_002885172.1 ribose ABC transporter permease -
KU668_RS01170 (250390) 250390..251910 - 1521 WP_251336448.1 sugar ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34653.14 Da        Isoelectric Point: 5.4707

>T207991 WP_019724882.1 NZ_CP077820:246299-247216 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CITQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

>T207991 NZ_CP103557:186695-186802 [Escherichia coli O25b:H4-ST131]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28548.92 Da        Isoelectric Point: 10.0870

>AT207991 WP_004177809.1 NZ_CP077820:245535-246293 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp

>AT207991 NZ_CP103557:c186638-186581 [Escherichia coli O25b:H4-ST131]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483YLF8

Antitoxin

Source ID Structure
AlphaFold DB A6TH05

References