Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 76053..76696 Replicon plasmid pFF1023_1
Accession NZ_CP077819
Organism Klebsiella pneumoniae strain FF1023

Toxin (Protein)


Gene name vagD Uniprot ID A0A5Q9LNG2
Locus tag KU670_RS25610 Protein ID WP_048983057.1
Coordinates 76053..76469 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID R4IT22
Locus tag KU670_RS25615 Protein ID WP_016338373.1
Coordinates 76466..76696 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU670_RS25590 (KU670_25555) 71101..73209 - 2109 WP_016338368.1 peptidase domain-containing ABC transporter -
KU670_RS25595 (KU670_25560) 73199..74476 - 1278 WP_016338369.1 HlyD family secretion protein -
KU670_RS25600 75135..75671 + 537 WP_223825639.1 hypothetical protein -
KU670_RS25605 75689..76012 + 324 WP_085842301.1 hypothetical protein -
KU670_RS25610 (KU670_25570) 76053..76469 - 417 WP_048983057.1 type II toxin-antitoxin system VapC family toxin Toxin
KU670_RS25615 (KU670_25575) 76466..76696 - 231 WP_016338373.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
KU670_RS25620 (KU670_25580) 77233..77583 + 351 WP_000493378.1 hypothetical protein -
KU670_RS25625 (KU670_25585) 77634..78377 + 744 WP_065810654.1 hypothetical protein -
KU670_RS25630 (KU670_25590) 78374..79150 + 777 WP_148390519.1 site-specific integrase -
KU670_RS25635 (KU670_25595) 79208..79465 - 258 WP_148390518.1 hypothetical protein -
KU670_RS25640 (KU670_25600) 79594..79707 - 114 WP_187358162.1 hypothetical protein -
KU670_RS25645 (KU670_25605) 80453..81208 + 756 WP_001568031.1 replication initiation protein RepE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..88682 88682


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15022.52 Da        Isoelectric Point: 9.2957

>T207990 WP_048983057.1 NZ_CP077819:c76469-76053 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFARVPGLVLEDWVK

Download         Length: 417 bp

>T207990 NZ_CP103557:186212-186319 [Escherichia coli O25b:H4-ST131]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8751.77 Da        Isoelectric Point: 4.3533

>AT207990 WP_016338373.1 NZ_CP077819:c76696-76466 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWSSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp

>AT207990 NZ_CP103557:c186163-186098 [Escherichia coli O25b:H4-ST131]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Q9LNG2

Antitoxin

Source ID Structure
AlphaFold DB A0A5Q9LN61

References