Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2318048..2318564 Replicon chromosome
Accession NZ_CP077818
Organism Klebsiella pneumoniae strain FF1023

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag KU670_RS11150 Protein ID WP_002886902.1
Coordinates 2318280..2318564 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag KU670_RS11145 Protein ID WP_002886901.1
Coordinates 2318048..2318290 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU670_RS11130 (KU670_11140) 2314076..2314816 + 741 WP_002886899.1 KDGP aldolase family protein -
KU670_RS11135 (KU670_11145) 2314883..2316037 + 1155 WP_251347522.1 lactonase family protein -
KU670_RS11140 (KU670_11150) 2316060..2317970 + 1911 WP_009486549.1 PRD domain-containing protein -
KU670_RS11145 (KU670_11155) 2318048..2318290 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KU670_RS11150 (KU670_11160) 2318280..2318564 + 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KU670_RS11155 (KU670_11165) 2318568..2319032 - 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KU670_RS11160 (KU670_11170) 2319273..2321411 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
KU670_RS11165 (KU670_11175) 2321768..2322511 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
KU670_RS11170 (KU670_11180) 2322514..2322687 - 174 WP_032408826.1 hypothetical protein -
KU670_RS11175 (KU670_11185) 2322817..2323080 + 264 WP_251347569.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T207977 WP_002886902.1 NZ_CP077818:2318280-2318564 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T207977 NZ_CP103552:14842-15324 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT207977 WP_002886901.1 NZ_CP077818:2318048-2318290 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT207977 NZ_CP103552:14588-14854 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References