Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 934744..935401 Replicon chromosome
Accession NZ_CP077818
Organism Klebsiella pneumoniae strain FF1023

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag KU670_RS04420 Protein ID WP_002916310.1
Coordinates 934744..935154 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag KU670_RS04425 Protein ID WP_002916312.1
Coordinates 935135..935401 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU670_RS04400 (KU670_04400) 930744..932477 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
KU670_RS04405 (KU670_04405) 932483..933196 - 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KU670_RS04410 (KU670_04410) 933219..934115 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
KU670_RS04415 (KU670_04415) 934216..934737 + 522 WP_004144730.1 flavodoxin FldB -
KU670_RS04420 (KU670_04420) 934744..935154 - 411 WP_002916310.1 protein YgfX Toxin
KU670_RS04425 (KU670_04425) 935135..935401 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
KU670_RS04430 (KU670_04430) 935647..936630 + 984 WP_251347472.1 tRNA-modifying protein YgfZ -
KU670_RS04435 (KU670_04435) 936729..937388 - 660 WP_002916317.1 hemolysin III family protein -
KU670_RS04440 (KU670_04440) 937552..937863 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
KU670_RS04445 (KU670_04445) 937913..938641 + 729 WP_117063896.1 MurR/RpiR family transcriptional regulator -
KU670_RS04450 (KU670_04450) 938760..940193 + 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T207974 WP_002916310.1 NZ_CP077818:c935154-934744 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T207974 NZ_CP103550:c5287493-5287110 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT207974 WP_002916312.1 NZ_CP077818:c935401-935135 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT207974 NZ_CP103550:c5287735-5287493 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References