Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 3537087..3537790 Replicon chromosome
Accession NZ_CP077816
Organism Klebsiella pneumoniae strain FF1043

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag KU669_RS17220 Protein ID WP_032439164.1
Coordinates 3537087..3537428 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag KU669_RS17225 Protein ID WP_048332320.1
Coordinates 3537449..3537790 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU669_RS17190 (KU669_17150) 3532286..3532960 + 675 WP_004186809.1 hypothetical protein -
KU669_RS17195 (KU669_17155) 3532962..3533309 + 348 WP_004186808.1 hypothetical protein -
KU669_RS17200 (KU669_17160) 3533312..3533791 + 480 WP_004192264.1 type VI secretion system tube protein TssD -
KU669_RS17205 3533984..3534332 - 349 Protein_3381 hypothetical protein -
KU669_RS17210 (KU669_17165) 3534351..3535462 - 1112 Protein_3382 IS3 family transposase -
KU669_RS17215 (KU669_17170) 3535830..3536837 - 1008 WP_032439165.1 restriction endonuclease -
KU669_RS17220 (KU669_17175) 3537087..3537428 - 342 WP_032439164.1 TA system toxin CbtA family protein Toxin
KU669_RS17225 (KU669_17180) 3537449..3537790 - 342 WP_048332320.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KU669_RS17230 (KU669_17185) 3537801..3538343 - 543 WP_032439162.1 DNA repair protein RadC -
KU669_RS17235 (KU669_17190) 3538356..3538799 - 444 WP_032439161.1 antirestriction protein -
KU669_RS17240 (KU669_17195) 3538830..3539650 - 821 Protein_3388 DUF932 domain-containing protein -
KU669_RS17245 (KU669_17200) 3539770..3540243 - 474 WP_032439159.1 hypothetical protein -
KU669_RS17250 (KU669_17205) 3540315..3540767 - 453 WP_080975604.1 hypothetical protein -
KU669_RS17255 (KU669_17210) 3540803..3541519 - 717 WP_072023689.1 WYL domain-containing protein -
KU669_RS17260 (KU669_17215) 3541763..3542638 - 876 WP_032439157.1 GTPase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3532962..3562633 29671


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-109)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12620.54 Da        Isoelectric Point: 8.0323

>T207967 WP_032439164.1 NZ_CP077816:c3537428-3537087 [Klebsiella pneumoniae]
MKTLPATTPQAATLCLSPVAVWQMLIARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRRGF
NWQEQSPYLGAVDILRARQATGILKRNRISAAR

Download         Length: 342 bp

>T207967 NZ_CP103550:1985467-1985569 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12755.40 Da        Isoelectric Point: 6.6921

>AT207967 WP_048332320.1 NZ_CP077816:c3537790-3537449 [Klebsiella pneumoniae]
MKSTGSENDSFLQWGLNRNVTPCFGARLVQEGNRLHYLVDRASITGKFSNAESLKLDEVFPRFISQMESMLTTGEMNPRY
AHCVTLYHNGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 342 bp

>AT207967 NZ_CP103550:c1985576-1985431 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References