Detailed information of TA system TA207967

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 3537087..3537790
• Replicon: chromosome
• Accession: NZ_CP077816
• Organism: Klebsiella pneumoniae strain FF1043

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: KU669_RS17220
• Protein ID: WP_032439164.1
• Coordinates: 3537087..3537428 (-)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: KU669_RS17225
• Protein ID: WP_048332320.1
• Coordinates: 3537449..3537790 (-)
• Length: 114 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU669_RS17190 (KU669_17150)	3532286..3532960	+	675	WP_004186809.1	hypothetical protein	-
KU669_RS17195 (KU669_17155)	3532962..3533309	+	348	WP_004186808.1	hypothetical protein	-
KU669_RS17200 (KU669_17160)	3533312..3533791	+	480	WP_004192264.1	type VI secretion system tube protein TssD	-
KU669_RS17205	3533984..3534332	-	349	Protein_3381	hypothetical protein	-
KU669_RS17210 (KU669_17165)	3534351..3535462	-	1112	Protein_3382	IS3 family transposase	-
KU669_RS17215 (KU669_17170)	3535830..3536837	-	1008	WP_032439165.1	restriction endonuclease	-
KU669_RS17220 (KU669_17175)	3537087..3537428	-	342	WP_032439164.1	TA system toxin CbtA family protein	Toxin
KU669_RS17225 (KU669_17180)	3537449..3537790	-	342	WP_048332320.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
KU669_RS17230 (KU669_17185)	3537801..3538343	-	543	WP_032439162.1	DNA repair protein RadC	-
KU669_RS17235 (KU669_17190)	3538356..3538799	-	444	WP_032439161.1	antirestriction protein	-
KU669_RS17240 (KU669_17195)	3538830..3539650	-	821	Protein_3388	DUF932 domain-containing protein	-
KU669_RS17245 (KU669_17200)	3539770..3540243	-	474	WP_032439159.1	hypothetical protein	-
KU669_RS17250 (KU669_17205)	3540315..3540767	-	453	WP_080975604.1	hypothetical protein	-
KU669_RS17255 (KU669_17210)	3540803..3541519	-	717	WP_072023689.1	WYL domain-containing protein	-
KU669_RS17260 (KU669_17215)	3541763..3542638	-	876	WP_032439157.1	GTPase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3532962..3562633	29671

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-109)

Antitoxin

• Antitoxin CbeA (13-112)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12620.54 Da
• Isoelectric Point: 8.0323

>T207967 WP_032439164.1 NZ_CP077816:c3537428-3537087 [Klebsiella pneumoniae]
MKTLPATTPQAATLCLSPVAVWQMLIARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRRGF
NWQEQSPYLGAVDILRARQATGILKRNRISAAR

Nucleotide

• Length: 342 bp

>T207967 NZ_CP103550:1985467-1985569 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 114 a.a.
• Molecular weight: 12755.40 Da
• Isoelectric Point: 6.6921

>AT207967 WP_048332320.1 NZ_CP077816:c3537790-3537449 [Klebsiella pneumoniae]
MKSTGSENDSFLQWGLNRNVTPCFGARLVQEGNRLHYLVDRASITGKFSNAESLKLDEVFPRFISQMESMLTTGEMNPRY
AHCVTLYHNGFTCEADTLGSCGYVYIAVYPTQR

Nucleotide

• Length: 342 bp

>AT207967 NZ_CP103550:c1985576-1985431 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT