207965

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2915190..2915809 Replicon chromosome
Accession NZ_CP077816
Organism Klebsiella pneumoniae strain FF1043

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag KU669_RS14200 Protein ID WP_002892050.1
Coordinates 2915591..2915809 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag KU669_RS14195 Protein ID WP_002892066.1
Coordinates 2915190..2915564 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU669_RS14185 (KU669_14145) 2910342..2911535 + 1194 WP_061891555.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
KU669_RS14190 (KU669_14150) 2911558..2914704 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
KU669_RS14195 (KU669_14155) 2915190..2915564 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
KU669_RS14200 (KU669_14160) 2915591..2915809 + 219 WP_002892050.1 HHA domain-containing protein Toxin
KU669_RS14205 (KU669_14165) 2915968..2916534 + 567 WP_251356718.1 maltose O-acetyltransferase -
KU669_RS14210 (KU669_14170) 2916506..2916646 - 141 WP_004147370.1 hypothetical protein -
KU669_RS14215 (KU669_14175) 2916667..2917137 + 471 WP_002892026.1 YlaC family protein -
KU669_RS14220 (KU669_14180) 2917112..2918563 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
KU669_RS14225 (KU669_14185) 2918664..2919362 + 699 WP_004177238.1 GNAT family protein -
KU669_RS14230 (KU669_14190) 2919359..2919499 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
KU669_RS14235 (KU669_14195) 2919499..2919762 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T207965 WP_002892050.1 NZ_CP077816:2915591-2915809 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T207965 NZ_CP103550:351841-352188 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT207965 WP_002892066.1 NZ_CP077816:2915190-2915564 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT207965 NZ_CP103550:352188-352487 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCAGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References