Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/UPF0150(antitoxin) |
| Location | 1967548..1968179 | Replicon | chromosome |
| Accession | NZ_CP077816 | ||
| Organism | Klebsiella pneumoniae strain FF1043 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | A0A1Q8YTV3 |
| Locus tag | KU669_RS09765 | Protein ID | WP_012542177.1 |
| Coordinates | 1968003..1968179 (-) | Length | 59 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | A0A2X1QFN9 |
| Locus tag | KU669_RS09760 | Protein ID | WP_012542176.1 |
| Coordinates | 1967548..1967955 (-) | Length | 136 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KU669_RS09720 (KU669_09685) | 1963328..1963762 | - | 435 | WP_012542168.1 | phage terminase small subunit P27 family | - |
| KU669_RS09725 (KU669_09690) | 1964012..1964443 | - | 432 | WP_251357313.1 | hypothetical protein | - |
| KU669_RS09730 (KU669_09695) | 1964440..1964757 | - | 318 | WP_016160653.1 | hypothetical protein | - |
| KU669_RS09735 (KU669_09700) | 1964709..1965071 | - | 363 | WP_014228901.1 | HNH endonuclease | - |
| KU669_RS09740 (KU669_09705) | 1965055..1965216 | - | 162 | WP_023328098.1 | hypothetical protein | - |
| KU669_RS09745 (KU669_09710) | 1965298..1965774 | - | 477 | WP_050583645.1 | DUF2514 domain-containing protein | - |
| KU669_RS09750 (KU669_09715) | 1965807..1966337 | - | 531 | WP_023328100.1 | lysozyme | - |
| KU669_RS09755 (KU669_09720) | 1966315..1966551 | - | 237 | WP_004111739.1 | class II holin family protein | - |
| KU669_RS09760 (KU669_09725) | 1967548..1967955 | - | 408 | WP_012542176.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| KU669_RS09765 (KU669_09730) | 1968003..1968179 | - | 177 | WP_012542177.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| KU669_RS09770 (KU669_09735) | 1968544..1969689 | + | 1146 | WP_023328101.1 | nucleoid-associated protein | - |
| KU669_RS09775 (KU669_09740) | 1969679..1970905 | + | 1227 | WP_251357314.1 | hypothetical protein | - |
| KU669_RS09780 (KU669_09745) | 1970900..1971244 | - | 345 | WP_032435861.1 | antiterminator Q family protein | - |
| KU669_RS09785 (KU669_09750) | 1971257..1972288 | - | 1032 | WP_251357315.1 | DUF968 domain-containing protein | - |
| KU669_RS09790 (KU669_09755) | 1972488..1972880 | - | 393 | WP_251357316.1 | DNA-binding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1935927..1988793 | 52866 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 59 a.a. Molecular weight: 6632.83 Da Isoelectric Point: 11.0174
>T207964 WP_012542177.1 NZ_CP077816:c1968179-1968003 [Klebsiella pneumoniae]
VKQSELRRWLAAQGAEFKDGTNHLKIYLNGKQTVMPRHPGKEIPEPLRKAILKQLGIK
VKQSELRRWLAAQGAEFKDGTNHLKIYLNGKQTVMPRHPGKEIPEPLRKAILKQLGIK
Download Length: 177 bp
>T207964 NZ_CP103550:325880-326248 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA
Antitoxin
Download Length: 136 a.a. Molecular weight: 14977.99 Da Isoelectric Point: 4.4277
>AT207964 WP_012542176.1 NZ_CP077816:c1967955-1967548 [Klebsiella pneumoniae]
MRYPVIFEHDETGWAVFFPDIPEAMTGGETREEALEMAQDALVTAFDFYFDDRREIPAPSAEGDAFVEVPASVAAKVLLL
NRLVSTNTSNADLARMINTRPQEVQRIVSLGHSTKIDTIQKALSALGQKMEIVVH
MRYPVIFEHDETGWAVFFPDIPEAMTGGETREEALEMAQDALVTAFDFYFDDRREIPAPSAEGDAFVEVPASVAAKVLLL
NRLVSTNTSNADLARMINTRPQEVQRIVSLGHSTKIDTIQKALSALGQKMEIVVH
Download Length: 408 bp
>AT207964 NZ_CP103550:325662-325883 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1Q8YTV3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2X1QFN9 |