Detailed information of TA system TA207963

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 1458055..1459643
• Replicon: chromosome
• Accession: NZ_CP077816
• Organism: Klebsiella pneumoniae strain FF1043

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A486BIX7
• Locus tag: KU669_RS07195
• Protein ID: WP_040151071.1
• Coordinates: 1458055..1459377 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: KU669_RS07200
• Protein ID: WP_251357477.1
• Coordinates: 1459377..1459643 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU669_RS07180 (KU669_07145)	1453111..1455612	+	2502	WP_061891829.1	fimbria/pilus outer membrane usher protein	-
KU669_RS07185 (KU669_07150)	1455600..1456604	+	1005	WP_004184029.1	fimbrial protein	-
KU669_RS07190 (KU669_07155)	1456746..1458038	+	1293	WP_117078055.1	glycoside hydrolase family 10 protein	-
KU669_RS07195 (KU669_07160)	1458055..1459377	-	1323	WP_040151071.1	type II toxin-antitoxin system HipA family toxin	Toxin
KU669_RS07200 (KU669_07165)	1459377..1459643	-	267	WP_251357477.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
KU669_RS07205 (KU669_07170)	1459909..1460235	-	327	WP_004176200.1	hydroxyisourate hydrolase	-
KU669_RS07210 (KU669_07175)	1460232..1460732	-	501	WP_004176202.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
KU669_RS07215 (KU669_07180)	1460710..1462089	-	1380	WP_251357244.1	nucleobase:cation symporter-2 family protein	-
KU669_RS07220 (KU669_07185)	1462435..1463589	+	1155	WP_251357245.1	FAD-dependent urate hydroxylase HpxO	-
KU669_RS07225 (KU669_07190)	1463570..1464493	-	924	WP_002904781.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49199.47 Da
• Isoelectric Point: 7.2488

>T207963 WP_040151071.1 NZ_CP077816:c1459377-1458055 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPDIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T207963 NZ_CP103548:c5292410-5292192 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9934.32 Da
• Isoelectric Point: 8.5912

>AT207963 WP_251357477.1 NZ_CP077816:c1459643-1459377 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDVLARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT207963 NZ_CP103548:c5292811-5292437 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Structures

Toxin

• AlphaFold DB: A0A486BIX7