Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3096689..3097490 Replicon chromosome
Accession NC_004337
Organism Shigella flexneri 2a str. 301

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0H2VZI7
Locus tag SF2999 Protein ID NP_708773.1
Coordinates 3097113..3097490 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0H2VX33
Locus tag SF2998 Protein ID NP_708772.1
Coordinates 3096689..3097066 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SF2993 3093310..3093765 + 456 NP_708767.1 hypothetical protein -
SF2993a 3093884..3094072 - 189 YP_008439280.1 hypothetical protein -
SF2994 3094176..3094994 + 819 NP_708768.1 hypothetical protein -
SF2995 3095336..3095809 + 474 NP_708769.2 hypothetical protein -
SF2996 3095810..3096301 + 492 NP_708770.1 RADC family DNA repair protein -
SF2997 3096388..3096609 + 222 NP_708771.1 hypothetical protein -
SF2998 3096689..3097066 + 378 NP_708772.1 structural protein Antitoxin
SF2999 3097113..3097490 + 378 NP_708773.1 hypothetical protein Toxin
SF3000 3097487..3097975 + 489 NP_708774.1 hypothetical protein -
SF3001 3097995..3098192 + 198 NP_708775.1 hypothetical protein -
SF3002 3098277..3099119 + 843 NP_708776.1 hypothetical protein -
SF3003 3099722..3100930 + 1209 NP_708777.1 insertion element iso-IS10R transposase -
SF3004 3101189..3101479 + 291 NP_708778.1 hypothetical protein -
SF3005 3101873..3102181 + 309 NP_708779.1 insertion sequence IS3 transposase InsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13971.82 Da        Isoelectric Point: 6.8608

>T20796 NP_708773.1 NC_004337:3097113-3097490 [Shigella flexneri 2a str. 301]
MNTLPDTHVREASGCPSPITIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPEAKQ

Download         Length: 378 bp

>T20796 NC_004337:3097113-3097490 [Shigella flexneri 2a str. 301]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCATCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGAATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
TAACTACAGAACGGTAAATAACATTACCCGGGGGAAGCATCCGGAAGCGAAACAATGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13698.52 Da        Isoelectric Point: 5.9505

>AT20796 NP_708772.1 NC_004337:3096689-3097066 [Shigella flexneri 2a str. 301]
VSDTLPGTTPPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDVDAYHLDQAFPLLMKQLELMLTGG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPATTV

Download         Length: 378 bp

>AT20796 NC_004337:3096689-3097066 [Shigella flexneri 2a str. 301]
GTGTCAGACACACTCCCCGGGACAACGCCTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCCCGACTGGTACAGGAGGGTAACCGCCTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCAGGT
TCAGCGACGTAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACTGGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCGCCCGCAACCACCGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2VZI7

Antitoxin

Source ID Structure
PDB 2INW
AlphaFold DB A0A0H2VX33

References