Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2974330..2974984 Replicon chromosome
Accession NC_004337
Organism Shigella flexneri 2a str. 301

Toxin (Protein)


Gene name cptA Uniprot ID A0A384L4J0
Locus tag SF2882 Protein ID NP_708660.1
Coordinates 2974330..2974737 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q83JU2
Locus tag SF2883 Protein ID NP_708661.1
Coordinates 2974718..2974984 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SF2878 2970287..2972020 - 1734 NP_708656.1 ssDNA exonuclease RecJ -
SF2879 2972026..2972736 - 711 NP_708657.1 protein disulfide isomerase -
SF2880 2972761..2973657 - 897 NP_708658.1 site-specific tyrosine recombinase XerD -
SF2881 2973769..2974290 + 522 NP_708659.1 flavodoxin FldB -
SF2882 2974330..2974737 - 408 NP_708660.1 hypothetical protein Toxin
SF2883 2974718..2974984 - 267 NP_708661.1 hypothetical protein Antitoxin
SF2884 2975227..2976207 + 981 NP_708662.1 global regulator -
SF2885 2976403..2977062 - 660 NP_708663.1 hemolysin -
SF2887 2977581..2979014 + 1434 NP_708664.2 6-phospho-beta-glucosidase -
SF2888 2979071..2979814 - 744 NP_708665.2 NAD(P)-binding oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15978.91 Da        Isoelectric Point: 10.9373

>T20795 NP_708660.1 NC_004337:c2974737-2974330 [Shigella flexneri 2a str. 301]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRCINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T20795 NC_004337:c2974737-2974330 [Shigella flexneri 2a str. 301]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTATTTGATTGCG
TTCGCAGCCAGCGGTGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10529.09 Da        Isoelectric Point: 5.1599

>AT20795 NP_708661.1 NC_004337:c2974984-2974718 [Shigella flexneri 2a str. 301]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEIMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT20795 NC_004337:c2974984-2974718 [Shigella flexneri 2a str. 301]
ATGGACATTAACAACAAAGCCCGAATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATAATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A384L4J0

Antitoxin

Source ID Structure
AlphaFold DB Q83JU2

References