Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 3919458..3921046 Replicon chromosome
Accession NZ_CP077814
Organism Klebsiella pneumoniae strain FF1076

Toxin (Protein)


Gene name hipA Uniprot ID A0A486BIX7
Locus tag KU667_RS19040 Protein ID WP_040151071.1
Coordinates 3919724..3921046 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag KU667_RS19035 Protein ID WP_002904790.1
Coordinates 3919458..3919724 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU667_RS19010 (KU667_18970) 3914608..3915531 + 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -
KU667_RS19015 (KU667_18975) 3915512..3916666 - 1155 WP_065809063.1 FAD-dependent urate hydroxylase HpxO -
KU667_RS19020 (KU667_18980) 3917012..3918391 + 1380 WP_004199850.1 nucleobase:cation symporter-2 family protein -
KU667_RS19025 (KU667_18985) 3918369..3918869 + 501 WP_251340949.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
KU667_RS19030 (KU667_18990) 3918866..3919192 + 327 WP_004176200.1 hydroxyisourate hydrolase -
KU667_RS19035 (KU667_18995) 3919458..3919724 + 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
KU667_RS19040 (KU667_19000) 3919724..3921046 + 1323 WP_040151071.1 type II toxin-antitoxin system HipA family toxin Toxin
KU667_RS19045 (KU667_19005) 3921063..3922355 - 1293 WP_015958402.1 glycoside hydrolase family 10 protein -
KU667_RS19050 (KU667_19010) 3922497..3923501 - 1005 WP_009308876.1 fimbrial protein -
KU667_RS19055 (KU667_19015) 3923489..3925990 - 2502 WP_251340950.1 fimbria/pilus outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49199.47 Da        Isoelectric Point: 7.2488

>T207937 WP_040151071.1 NZ_CP077814:3919724-3921046 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPDIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T207937 NZ_CP103544:2703965-2704072 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT207937 WP_002904790.1 NZ_CP077814:3919458-3919724 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT207937 NZ_CP103544:c2703915-2703852 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486BIX7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References