Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1801070..1801586 Replicon chromosome
Accession NZ_CP077814
Organism Klebsiella pneumoniae strain FF1076

Toxin (Protein)


Gene name relE Uniprot ID A0A085DK79
Locus tag KU667_RS08785 Protein ID WP_009309309.1
Coordinates 1801302..1801586 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag KU667_RS08780 Protein ID WP_002886901.1
Coordinates 1801070..1801312 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU667_RS08765 (KU667_08765) 1797098..1797838 + 741 WP_004186692.1 KDGP aldolase family protein -
KU667_RS08770 (KU667_08770) 1797905..1799059 + 1155 WP_002886900.1 lactonase family protein -
KU667_RS08775 (KU667_08775) 1799082..1800992 + 1911 WP_251341083.1 PRD domain-containing protein -
KU667_RS08780 (KU667_08780) 1801070..1801312 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KU667_RS08785 (KU667_08785) 1801302..1801586 + 285 WP_009309309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KU667_RS08790 (KU667_08790) 1801590..1802054 - 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KU667_RS08795 (KU667_08795) 1802296..1804434 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
KU667_RS08800 (KU667_08800) 1804791..1805534 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
KU667_RS08805 (KU667_08805) 1805537..1805710 - 174 WP_004146781.1 hypothetical protein -
KU667_RS08810 (KU667_08810) 1805795..1806103 + 309 WP_016947038.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11141.99 Da        Isoelectric Point: 10.3787

>T207934 WP_009309309.1 NZ_CP077814:1801302-1801586 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T207934 NZ_CP103544:c2471408-2471232 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT207934 WP_002886901.1 NZ_CP077814:1801070-1801312 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT207934 NZ_CP103544:c2471186-2470770 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCGTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTTGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085DK79

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References