207929

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 428602..429259 Replicon chromosome
Accession NZ_CP077814
Organism Klebsiella pneumoniae strain FF1076

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag KU667_RS02090 Protein ID WP_002916310.1
Coordinates 428602..429012 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag KU667_RS02095 Protein ID WP_002916312.1
Coordinates 428993..429259 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU667_RS02070 (KU667_02070) 424602..426335 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
KU667_RS02075 (KU667_02075) 426341..427054 - 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KU667_RS02080 (KU667_02080) 427077..427973 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
KU667_RS02085 (KU667_02085) 428074..428595 + 522 WP_002916308.1 flavodoxin FldB -
KU667_RS02090 (KU667_02090) 428602..429012 - 411 WP_002916310.1 protein YgfX Toxin
KU667_RS02095 (KU667_02095) 428993..429259 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
KU667_RS02100 (KU667_02100) 429505..430488 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
KU667_RS02105 (KU667_02105) 430639..431298 - 660 WP_002916317.1 hemolysin III family protein -
KU667_RS02110 (KU667_02110) 431462..431773 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
KU667_RS02115 (KU667_02115) 431823..432551 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
KU667_RS02120 (KU667_02120) 432670..434103 + 1434 WP_004185559.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T207929 WP_002916310.1 NZ_CP077814:c429012-428602 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T207929 NZ_CP103544:1800654-1800905 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT207929 WP_002916312.1 NZ_CP077814:c429259-428993 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT207929 NZ_CP103544:1800902-1801156 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCAGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References