Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4762302..4762959 Replicon chromosome
Accession NZ_CP077812
Organism Klebsiella pneumoniae strain FF1083

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag KU672_RS23190 Protein ID WP_002916310.1
Coordinates 4762549..4762959 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag KU672_RS23185 Protein ID WP_002916312.1
Coordinates 4762302..4762568 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU672_RS23160 (4757458) 4757458..4758891 - 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -
KU672_RS23165 (4759010) 4759010..4759738 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
KU672_RS23170 (4759788) 4759788..4760099 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
KU672_RS23175 (4760263) 4760263..4760922 + 660 WP_002916317.1 hemolysin III family protein -
KU672_RS23180 (4761073) 4761073..4762056 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
KU672_RS23185 (4762302) 4762302..4762568 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
KU672_RS23190 (4762549) 4762549..4762959 + 411 WP_002916310.1 protein YgfX Toxin
KU672_RS23195 (4762966) 4762966..4763487 - 522 WP_004144730.1 flavodoxin FldB -
KU672_RS23200 (4763588) 4763588..4764484 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
KU672_RS23205 (4764507) 4764507..4765220 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KU672_RS23210 (4765226) 4765226..4766959 + 1734 WP_032105216.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T207928 WP_002916310.1 NZ_CP077812:4762549-4762959 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T207928 NZ_CP103544:1287543-1287941 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTTATTGAAGGTTTCGTATCTCGTTTGGTAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT207928 WP_002916312.1 NZ_CP077812:4762302-4762568 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT207928 NZ_CP103544:1287316-1287543 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAAGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References