Detailed information of TA system TA207926

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 4304811..4305397
• Replicon: chromosome
• Accession: NZ_CP077812
• Organism: Klebsiella pneumoniae strain FF1083

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: KU672_RS20810
• Protein ID: WP_021312828.1
• Coordinates: 4305029..4305397 (+)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: W9B1V1
• Locus tag: KU672_RS20805
• Protein ID: WP_004174006.1
• Coordinates: 4304811..4305032 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU672_RS20785 (4300968)	4300968..4301894	+	927	WP_002920807.1	high-affinity branched-chain amino acid ABC transporter permease LivH	-
KU672_RS20790 (4301891)	4301891..4303168	+	1278	WP_004174005.1	branched chain amino acid ABC transporter permease LivM	-
KU672_RS20795 (4303165)	4303165..4303932	+	768	WP_002920803.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG	-
KU672_RS20800 (4303934)	4303934..4304647	+	714	WP_004145133.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF	-
KU672_RS20805 (4304811)	4304811..4305032	+	222	WP_004174006.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
KU672_RS20810 (4305029)	4305029..4305397	+	369	WP_021312828.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
KU672_RS20815 (4305670)	4305670..4306986	+	1317	WP_002920796.1	sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB	-
KU672_RS20820 (4307093)	4307093..4307980	+	888	WP_002920792.1	sn-glycerol-3-phosphate ABC transporter permease UgpA	-
KU672_RS20825 (4307977)	4307977..4308822	+	846	WP_004145129.1	sn-glycerol-3-phosphate ABC transporter permease UgpE	-
KU672_RS20830 (4308824)	4308824..4309894	+	1071	WP_004150074.1	sn-glycerol-3-phosphate import ATP-binding protein UgpC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4264656..4310631	45975

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Death on curing protein (1-121)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-50)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13578.96 Da
• Isoelectric Point: 8.5493

>T207926 WP_021312828.1 NZ_CP077812:4305029-4305397 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGYIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Nucleotide

• Length: 369 bp

>T207926 NZ_CP103544:863419-863826 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8151.15 Da
• Isoelectric Point: 4.7769

>AT207926 WP_004174006.1 NZ_CP077812:4304811-4305032 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Nucleotide

• Length: 222 bp

>AT207926 NZ_CP103544:863172-863438 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTAATCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A5E5YJY7