Detailed information of TA system TA207923

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 3415165..3415681
• Replicon: chromosome
• Accession: NZ_CP077812
• Organism: Klebsiella pneumoniae strain FF1083

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KU672_RS16610
• Protein ID: WP_040170298.1
• Coordinates: 3415165..3415449 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4Y888
• Locus tag: KU672_RS16615
• Protein ID: WP_002886901.1
• Coordinates: 3415439..3415681 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU672_RS16585 (3410582)	3410582..3410890	-	309	WP_004186703.1	PTS sugar transporter subunit IIB	-
KU672_RS16590 (3410975)	3410975..3411148	+	174	WP_004222159.1	hypothetical protein	-
KU672_RS16595 (3411151)	3411151..3411894	+	744	WP_002886905.1	MurR/RpiR family transcriptional regulator	-
KU672_RS16600 (3412251)	3412251..3414389	+	2139	WP_064148390.1	anaerobic ribonucleoside-triphosphate reductase	-
KU672_RS16605 (3414697)	3414697..3415161	+	465	WP_004178375.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
KU672_RS16610 (3415165)	3415165..3415449	-	285	WP_040170298.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KU672_RS16615 (3415439)	3415439..3415681	-	243	WP_002886901.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
KU672_RS16620 (3415759)	3415759..3417669	-	1911	WP_004152270.1	PRD domain-containing protein	-
KU672_RS16625 (3417692)	3417692..3418846	-	1155	WP_064148391.1	lactonase family protein	-
KU672_RS16630 (3418913)	3418913..3419653	-	741	WP_009486551.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11186.06 Da
• Isoelectric Point: 10.3787

>T207923 WP_040170298.1 NZ_CP077812:c3415449-3415165 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGEMVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T207923 NZ_CP103544:267641-267871 [Escherichia coli]
CTGGATCAGCTATTTAAATCACCTTTACCTCAAGGAATCAAATGGACTGATATAGAATCTCTGGTTAAAGCGTTAGGCGG
AGAAATTAAGGAAGGTAGGGGGTCGCGCTGTAAGTTCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGT
CGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTGCGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9045.55 Da
• Isoelectric Point: 6.3340

>AT207923 WP_002886901.1 NZ_CP077812:c3415681-3415439 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT207923 NZ_CP103544:267868-268227 [Escherichia coli]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCTGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GLP0