207908

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4757858..4758515 Replicon chromosome
Accession NZ_CP077810
Organism Klebsiella pneumoniae strain FF904

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag KU662_RS23110 Protein ID WP_002916310.1
Coordinates 4758105..4758515 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag KU662_RS23105 Protein ID WP_002916312.1
Coordinates 4757858..4758124 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU662_RS23080 (4753066) 4753066..4754499 - 1434 WP_004185559.1 6-phospho-beta-glucosidase BglA -
KU662_RS23085 (4754618) 4754618..4755346 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
KU662_RS23090 (4755396) 4755396..4755707 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
KU662_RS23095 (4755871) 4755871..4756530 + 660 WP_002916317.1 hemolysin III family protein -
KU662_RS23100 (4756629) 4756629..4757612 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
KU662_RS23105 (4757858) 4757858..4758124 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
KU662_RS23110 (4758105) 4758105..4758515 + 411 WP_002916310.1 protein YgfX Toxin
KU662_RS23115 (4758522) 4758522..4759043 - 522 WP_002916308.1 flavodoxin FldB -
KU662_RS23120 (4759144) 4759144..4760040 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
KU662_RS23125 (4760063) 4760063..4760776 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KU662_RS23130 (4760782) 4760782..4762516 + 1735 Protein_4515 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T207908 WP_002916310.1 NZ_CP077810:4758105-4758515 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T207908 NZ_CP103540:1810229-1810483 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATTATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT207908 WP_002916312.1 NZ_CP077810:4757858-4758124 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT207908 NZ_CP103540:1809981-1810232 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References