Detailed information of TA system TA207905

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1(toxin)
• Location: 3899379..3900004
• Replicon: chromosome
• Accession: NZ_CP077810
• Organism: Klebsiella pneumoniae strain FF904

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: R4Y4A3
• Locus tag: KU662_RS18875
• Protein ID: WP_002882817.1
• Coordinates: 3899379..3899762 (-)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: KU662_RS18880
• Protein ID: WP_162557435.1
• Coordinates: 3899762..3900004 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU662_RS18860 (3896745)	3896745..3897647	+	903	WP_002882822.1	formate dehydrogenase subunit beta	-
KU662_RS18865 (3897644)	3897644..3898279	+	636	WP_002882818.1	formate dehydrogenase cytochrome b556 subunit	-
KU662_RS18870 (3898276)	3898276..3899205	+	930	WP_004150358.1	formate dehydrogenase accessory protein FdhE	-
KU662_RS18875 (3899379)	3899379..3899762	-	384	WP_002882817.1	type II toxin-antitoxin system VapC family toxin	Toxin
KU662_RS18880 (3899762)	3899762..3900004	-	243	WP_162557435.1	CopG family transcriptional regulator	Antitoxin
KU662_RS18885 (3900209)	3900209..3901126	+	918	WP_032417884.1	alpha/beta hydrolase	-
KU662_RS18890 (3901141)	3901141..3902082	-	942	WP_004178031.1	fatty acid biosynthesis protein FabY	-
KU662_RS18895 (3902127)	3902127..3902564	-	438	WP_002882809.1	D-aminoacyl-tRNA deacylase	-
KU662_RS18900 (3902561)	3902561..3903421	-	861	WP_004146232.1	virulence factor BrkB family protein	-
KU662_RS18905 (3903415)	3903415..3904014	-	600	WP_004151865.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (7-112)

Antitoxin

• Ribbon-helix-helix protein, CopG (13-47)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 14377.62 Da
• Isoelectric Point: 7.3178

>T207905 WP_002882817.1 NZ_CP077810:c3899762-3899379 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Nucleotide

• Length: 384 bp

>T207905 NZ_CP103540:860570-860977 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATCTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATCCACGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGCTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9557.79 Da
• Isoelectric Point: 4.3509

>AT207905 WP_162557435.1 NZ_CP077810:c3900004-3899762 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNISRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Nucleotide

• Length: 243 bp

>AT207905 NZ_CP103540:860323-860589 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAGTGTGACGATCCCGATC
TGTTTAACTGGCTGATGAACCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: A0A0H3GPK8