Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3426318..3426834 Replicon chromosome
Accession NZ_CP077810
Organism Klebsiella pneumoniae strain FF904

Toxin (Protein)


Gene name relE Uniprot ID A0A085DK79
Locus tag KU662_RS16620 Protein ID WP_009309309.1
Coordinates 3426318..3426602 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag KU662_RS16625 Protein ID WP_002886901.1
Coordinates 3426592..3426834 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU662_RS16595 (3421801) 3421801..3422109 - 309 WP_019725542.1 PTS sugar transporter subunit IIB -
KU662_RS16600 (3422194) 3422194..3422367 + 174 WP_019725541.1 hypothetical protein -
KU662_RS16605 (3422370) 3422370..3423113 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
KU662_RS16610 (3423470) 3423470..3425608 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
KU662_RS16615 (3425850) 3425850..3426314 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KU662_RS16620 (3426318) 3426318..3426602 - 285 WP_009309309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KU662_RS16625 (3426592) 3426592..3426834 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KU662_RS16630 (3426912) 3426912..3428822 - 1911 WP_004152270.1 PRD domain-containing protein -
KU662_RS16635 (3428845) 3428845..3429999 - 1155 WP_002886900.1 lactonase family protein -
KU662_RS16640 (3430066) 3430066..3430806 - 741 WP_032417761.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11141.99 Da        Isoelectric Point: 10.3787

>T207903 WP_009309309.1 NZ_CP077810:c3426602-3426318 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T207903 NZ_CP103540:c647598-647134 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAACCCCATTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT207903 WP_002886901.1 NZ_CP077810:c3426834-3426592 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT207903 NZ_CP103540:c647933-647598 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085DK79

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References