Detailed information of TA system TA207902

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 3341029..3341732
• Replicon: chromosome
• Accession: NZ_CP077810
• Organism: Klebsiella pneumoniae strain FF904

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: KU662_RS16245
• Protein ID: WP_017880111.1
• Coordinates: 3341029..3341370 (-)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: KU662_RS16250
• Protein ID: WP_050131139.1
• Coordinates: 3341391..3341732 (-)
• Length: 114 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU662_RS16215 (3336224)	3336224..3336898	+	675	WP_004186809.1	hypothetical protein	-
KU662_RS16220 (3336900)	3336900..3337247	+	348	WP_004186808.1	hypothetical protein	-
KU662_RS16225 (3337250)	3337250..3337729	+	480	WP_004192264.1	type VI secretion system tube protein TssD	-
KU662_RS16230 (3337922)	3337922..3338260	-	339	Protein_3183	hypothetical protein	-
KU662_RS16235 (3338279)	3338279..3339390	-	1112	Protein_3184	IS3 family transposase	-
KU662_RS16240 (3339758)	3339758..3340765	-	1008	WP_017880110.1	restriction endonuclease	-
KU662_RS16245 (3341029)	3341029..3341370	-	342	WP_017880111.1	TA system toxin CbtA family protein	Toxin
KU662_RS16250 (3341391)	3341391..3341732	-	342	WP_050131139.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
KU662_RS16255 (3341743)	3341743..3342285	-	543	WP_032417798.1	DNA repair protein RadC	-
KU662_RS16260 (3342298)	3342298..3342741	-	444	WP_032417797.1	antirestriction protein	-
KU662_RS16265 (3342772)	3342772..3343593	-	822	WP_032417795.1	DUF932 domain-containing protein	-
KU662_RS16270 (3343714)	3343714..3344187	-	474	WP_031280324.1	hypothetical protein	-
KU662_RS16275 (3344259)	3344259..3344711	-	453	WP_031280325.1	hypothetical protein	-
KU662_RS16280 (3344747)	3344747..3345463	-	717	WP_032417794.1	WYL domain-containing protein	-
KU662_RS16285 (3345707)	3345707..3346582	-	876	WP_017880120.1	GTPase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3336900..3368238	31338

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-109)

Antitoxin

• Antitoxin CbeA (13-111)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12811.73 Da
• Isoelectric Point: 8.4941

>T207902 WP_017880111.1 NZ_CP077810:c3341370-3341029 [Klebsiella pneumoniae]
MKTLPATNPQAATLYLSPVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRRGF
DWQEQSPYLRAVDIMRARQATGLLKRNRISAAR

Nucleotide

• Length: 342 bp

>T207902 NZ_CP103540:230249-230356 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Protein

• Length: 114 a.a.
• Molecular weight: 12821.45 Da
• Isoelectric Point: 6.3148

>AT207902 WP_050131139.1 NZ_CP077810:c3341732-3341391 [Klebsiella pneumoniae]
MKSTDSENDSFLKWGLNCNMTPCFGARLVQEGNRLHYLADRACITGEFSNAESLKLDEVFTRFIRQMESMLTTGEMNPRH
AHSVTLYHNGFTCEADTLGSCGYVYIAVYPTHR

Nucleotide

• Length: 342 bp

>AT207902 NZ_CP103540:c230201-230135 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT