Detailed information of TA system TA207874

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 506528..507044
• Replicon: chromosome
• Accession: NZ_CP077809
• Organism: Klebsiella pneumoniae strain FF923

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KU666_RS02405
• Protein ID: WP_021469513.1
• Coordinates: 506760..507044 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4Y888
• Locus tag: KU666_RS02400
• Protein ID: WP_002886901.1
• Coordinates: 506528..506770 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU666_RS02385 (502556)	502556..503296	+	741	WP_002886899.1	KDGP aldolase family protein	-
KU666_RS02390 (503363)	503363..504517	+	1155	WP_002886900.1	lactonase family protein	-
KU666_RS02395 (504540)	504540..506450	+	1911	WP_004152270.1	PRD domain-containing protein	-
KU666_RS02400 (506528)	506528..506770	+	243	WP_002886901.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
KU666_RS02405 (506760)	506760..507044	+	285	WP_021469513.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KU666_RS02410 (507048)	507048..507512	-	465	WP_004178375.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
KU666_RS02415 (507820)	507820..509958	-	2139	WP_004186701.1	anaerobic ribonucleoside-triphosphate reductase	-
KU666_RS02420 (510315)	510315..511058	-	744	WP_002886905.1	MurR/RpiR family transcriptional regulator	-
KU666_RS02425 (511061)	511061..511234	-	174	WP_032408826.1	hypothetical protein	-
KU666_RS02430 (511319)	511319..511627	+	309	WP_012737232.1	PTS sugar transporter subunit IIB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11083.95 Da
• Isoelectric Point: 10.4962

>T207874 WP_021469513.1 NZ_CP077809:506760-507044 [Klebsiella pneumoniae]
MTYELAFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T207874 NZ_CP103529:c4497498-4497325 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9045.55 Da
• Isoelectric Point: 6.3340

>AT207874 WP_002886901.1 NZ_CP077809:506528-506770 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT207874 NZ_CP103529:c4497822-4497526 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Antitoxin

• AlphaFold DB: A0A0H3GLP0