Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4799478..4800135 Replicon chromosome
Accession NZ_CP077806
Organism Klebsiella pneumoniae strain FF979

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag KU665_RS23085 Protein ID WP_002916310.1
Coordinates 4799725..4800135 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag KU665_RS23080 Protein ID WP_002916312.1
Coordinates 4799478..4799744 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU665_RS23055 (KU665_23000) 4794686..4796119 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
KU665_RS23060 (KU665_23005) 4796238..4796966 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
KU665_RS23065 (KU665_23010) 4797016..4797327 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
KU665_RS23070 (KU665_23015) 4797491..4798150 + 660 WP_002916317.1 hemolysin III family protein -
KU665_RS23075 (KU665_23020) 4798249..4799232 - 984 WP_016530681.1 tRNA-modifying protein YgfZ -
KU665_RS23080 (KU665_23025) 4799478..4799744 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
KU665_RS23085 (KU665_23030) 4799725..4800135 + 411 WP_002916310.1 protein YgfX Toxin
KU665_RS23090 (KU665_23035) 4800142..4800663 - 522 WP_251335899.1 flavodoxin FldB -
KU665_RS23095 (KU665_23040) 4800764..4801660 + 897 WP_191718205.1 site-specific tyrosine recombinase XerD -
KU665_RS23100 (KU665_23045) 4801683..4802396 + 714 WP_251335900.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KU665_RS23105 (KU665_23050) 4802402..4804135 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T207871 WP_002916310.1 NZ_CP077806:4799725-4800135 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T207871 NZ_CP103529:3945802-3946080 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT207871 WP_002916312.1 NZ_CP077806:4799478-4799744 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT207871 NZ_CP103529:3945539-3945799 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References